The expression of PRAME in chronic lymphoproliferative disorders

Autor(es)

Proto-Siqueira‚ R. ; Falcão‚ R.P. ; de Souza‚ C.A. ; Ismael‚ S.J. ; Zago‚ M.A.

• Tipo de documento: Artigo Científico
• Fonte: Leukemia Research; v. 27, n. 5, p. 393-396, 2003.

Resumo

The PRAME gene encodes an antigen recognized by autologous T lymphocytes and is expressed in trophoblasts, testis and frequently in human solid cancers and acute leukemias, making it a candidate for immunotherapy and for detecting MRD. We demonstrate expression of PRAME by RT-PCR in the peripheral blood or bone marrow of 26% of 58 patients with CLD (38 cases of CLL, 4 cases of PLL and 16 cases of NHL). Seven out 16 cases of MCL, 2 out 4 of PLL and 6 cases of CLL demonstrated some degree of gene expression. Thus, CLD are among the hematopoietic malignancies for which PRAME may be the target of immunological therapy or used to evaluate MRD. The stronger and more frequent expression of PRAME in MCL is apparently an additional distinguishing feature on this group of lymphoproliferative disorders. (C) 2002 Elsevier Science Ltd. All rights reserved. (AU)

• Processo FAPESP: 02/00217-5 - Clonagem e caracterizacao de um novo gene humano relacionado com a familia das forminas, com papel na reorganizacao do citoesqueleto.
• Beneficiário: Patricia Maria Bergamo Favaro
• Modalidade de apoio: Bolsas no Brasil - Doutorado
• Processo FAPESP: 00/03649-8 - As celulas neoplasicas da leucemia linfoide cronica expressam os genes de antigenos especificos de tumor?
• Beneficiário: Rodrigo Proto de Siqueira
• Modalidade de apoio: Bolsas no Brasil - Mestrado
• Processo FAPESP: 98/14247-6 - Center for Research on Cell-Based Therapy
• Beneficiário: Marco Antonio Zago
• Modalidade de apoio: Auxílio à Pesquisa - Centros de Pesquisa, Inovação e Difusão - CEPIDs