Influence of HLA-DRB-1 alleles on the production of antibody against CSP, MSP-1, AMA-1, and DBP in Brazilian individuals naturally infected with Plasmodium vivax

Autor(es):Mostrar menos -

Storti-Melo, Luciane Moreno ^{[1, 2]} ; da Costa, Daniela Reis ^[1] ; Souza-Neiras, Wanessa Christina ^{[1, 3]} ; Cassiano, Gustavo Capatti ^{[1, 4]} ; D'Almeida Couto, Vanja Suely Calvosa ^[5] ; Povoa, Marinete Marins ^[6] ; Soares, Irene da Silva ^[7] ; de Carvalho, Luzia Helena ^[8] ; Arevalo-Herrera, Myrian ^[9] ; Herrera, Socrates ^[9] ; Baptista Rossit, Andrea Regina ^[10] ; Cordeiro, Jose Antonio ^[11] ; de Mattos, Luiz Carlos ^[12] ; Dantas Machado, Ricardo Luiz ^[1]

Afiliação do(s) autor(es):Mostrar menos -

^[1] Fac Med Sao Jose do Rio Preto, Dept Doencas Dermatol Infecciosas & Parasitarias, Ctr Invest Microrganismos, BR-15090000 Sao Paulo - Brazil

^[2] Univ Fed Sergipe, Dept Biociencias, BR-49500000 Itabaiana, SE - Brazil

^[3] Univ Fed Triangulo Mineiro, Inst Ciencias Exatas Nat & Educ, BR-38025180 Uberaba, MC - Brazil

^[4] Univ Estadual Paulista, BR-15054000 Sao Paulo - Brazil

^[5] Nucleo Estadual Amapa CRDT, Minist Saude, BR-68900430 Macapa, Amapa - Brazil

^[6] Secretaria Vigilancia Saude, Inst Evandro Chagas, Lab Pesquisas Basicas Malaria, BR-6703000 Ananindeua, Para - Brazil

^[7] Univ Sao Paulo, Fac Ciencias Farmaceut, BR-05508900 Sao Paulo - Brazil

^[8] Fundacao Oswaldo Cruz, Ctr Pesquisas Rene Rachou, Lab Malaria, BR-30190002 Belo Horizonte, MG - Brazil

^[9] Univ Valle, Fac Salud, Inst Inmunol, Cali - Colombia

^[10] Univ Fed Fluminense, Inst Biomed, Dept Microbiol & Parasitol, BR-24210130 Rio De Janeiro - Brazil

^[11] Fac Med Sao Jose do Rio Preto, Dept Epidemiol, BR-15090000 Sao Paulo - Brazil

^[12] Fac Med Sao Jose do Rio Preto, Dept Biol Mol, Lab Imunohematol, BR-15090000 Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Acta Tropica; v. 121, n. 2, p. 152-155, FEB 2012.
• Citações Web of Science: 18

Resumo

We evaluated the influence of allelic frequency of the human leukocyte antigen (HLA) -DRB1 on the acquisition of antibody response against malaria sporozoite and merozoite peptides in patients with Plasmodium vivax malaria acquired in endemic areas of Brazil. IgG antibodies were detected by enzyme-linked immunosorbent assay against four peptides of circumsporozoite protein (CSP) (amino, carboxyl, and VK210 and VK247 repeats) and peptides of merozoite surface protein 1 (MSP-1), apical membrane antigen 1 (AMA-1), and Duffy-binding protein (DBP). We found an association between HLA-DR3 and HLA-DR5 alleles and lack of antibody response to CSP amino terminal, as well as an association between HILA-DR3 and the highest antibody response to MSP1 (Pv200L). In conclusion, we suggest a potential regulatory role of the H1A-DRB1 alleles in the production of antibodies to a conserved region of P. vivax CSP and MSP1 in Brazilian population exposed to malaria. (C) 2011 Elsevier B.V. All rights reserved. (AU)

• Processo FAPESP: 02/09546-1 - Epidemiologia e diagnóstico molecular de doenças infecciosas e parasitárias humanas
• Beneficiário: Andrea Regina de Souza Baptista
• Modalidade de apoio: Auxílio à Pesquisa - Jovens Pesquisadores