Focus on Vitamin D, Inflammation and Type 2 Diabetes

Autor(es)

Andrade Chagas, Carlos Eduardo ^[1] ; Borges, Maria Carolina ^[2] ; Martini, Lgia Araujo ^[2] ; Rogero, Marcelo Macedo ^[2]

Afiliação do(s) autor(es)

^[1] Sao Paulo State Univ, Inst Biosci, Dept Educ, Ctr Nutr Practice & Res, BR-18618970 Botucatu, SP - Brazil

^[2] Univ Sao Paulo, Sch Publ Hlth, Dept Nutr, BR-01246904 Sao Paulo - Brazil

• Tipo de documento: Artigo de Revisão
• Fonte: NUTRIENTS; v. 4, n. 1, p. 52-67, JAN 2012.
• Citações Web of Science: 89

Resumo

The initial observations linking vitamin D to type 2 diabetes in humans came from studies showing that both healthy and diabetic subjects had a seasonal variation of glycemic control. Currently, there is evidence supporting that vitamin D status is important to regulate some pathways related to type 2 diabetes development. Since the activation of inflammatory pathways interferes with normal metabolism and disrupts proper insulin signaling, it is hypothesized that vitamin D could influence glucose homeostasis by modulating inflammatory response. Human studies investigating the impact of vitamin D supplementation on inflammatory biomarkers of subjects with or at high risk of developing type 2 diabetes are scarce and have generated conflicting results. Based on available clinical and epidemiological data, the positive effects of vitamin D seem to be primarily related to its action on insulin secretion and sensitivity and secondary to its action on inflammation. Future studies specifically designed to investigate the role of vitamin D on type 2 diabetes using inflammation as the main outcome are urgently needed in order to provide a more robust link between vitamin D, inflammation and type 2 diabetes. (AU)

• Processo FAPESP: 10/08386-7 - Relação entre tecido adiposo e osso: interação metabólica entre vitamina d e genótipos para receptor de vitamina d (vdr), osteocalcina e leptina em indivíduos com síndrome metabólica participantes do estudo longitudional de saúde do adulto (elsa).
• Beneficiário: Carlos Eduardo Andrade Chagas
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 09/54395-0 - Efeito da ingestão do extrato aquoso de erva-mate (Ilex paraguariensis) sobre a expressão de proteínas envolvidas na resposta inflamatória e na regulação da via de sinalização da insulina no fígado e no músculo sóleo de ratos submetidos à dieta hiperlipídica
• Beneficiário: Marcelo Macedo Rogero
• Modalidade de apoio: Auxílio à Pesquisa - Regular