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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Focus on Vitamin D, Inflammation and Type 2 Diabetes

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Author(s):
Andrade Chagas, Carlos Eduardo [1] ; Borges, Maria Carolina [2] ; Martini, Lgia Araujo [2] ; Rogero, Marcelo Macedo [2]
Total Authors: 4
Affiliation:
[1] Sao Paulo State Univ, Inst Biosci, Dept Educ, Ctr Nutr Practice & Res, BR-18618970 Botucatu, SP - Brazil
[2] Univ Sao Paulo, Sch Publ Hlth, Dept Nutr, BR-01246904 Sao Paulo - Brazil
Total Affiliations: 2
Document type: Review article
Source: NUTRIENTS; v. 4, n. 1, p. 52-67, JAN 2012.
Web of Science Citations: 89
Abstract

The initial observations linking vitamin D to type 2 diabetes in humans came from studies showing that both healthy and diabetic subjects had a seasonal variation of glycemic control. Currently, there is evidence supporting that vitamin D status is important to regulate some pathways related to type 2 diabetes development. Since the activation of inflammatory pathways interferes with normal metabolism and disrupts proper insulin signaling, it is hypothesized that vitamin D could influence glucose homeostasis by modulating inflammatory response. Human studies investigating the impact of vitamin D supplementation on inflammatory biomarkers of subjects with or at high risk of developing type 2 diabetes are scarce and have generated conflicting results. Based on available clinical and epidemiological data, the positive effects of vitamin D seem to be primarily related to its action on insulin secretion and sensitivity and secondary to its action on inflammation. Future studies specifically designed to investigate the role of vitamin D on type 2 diabetes using inflammation as the main outcome are urgently needed in order to provide a more robust link between vitamin D, inflammation and type 2 diabetes. (AU)

FAPESP's process: 10/08386-7 - ADIPOSE TISSUE AND BONE: METABOLIC PATHWAY BETWEEN VITAMIN D AND VITAMIN D RECEPTOR (VDR), OSTECALCIN AND LEPTIN GENOTIPES IN METABOLIC SYNDROME INDIVIDUALS FROM LONGITUDINAL HEALTH STUDY (ELSA).
Grantee:Carlos Eduardo Andrade Chagas
Support Opportunities: Scholarships in Brazil - Post-Doctoral