MPL immunohistochemical expression as a novel marker for essential thrombocythemia and primary myelofibrosis differential diagnosis

Autor(es)

Ponce, Cesar Cilento ^[1] ; Chauffaille, Maria de Lourdes F. ^[2] ; Ihara, Silvia Saiuli M. ^[1] ; Silva, Maria Regina R. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Fed Sao Paulo, Dept Pathol, Sao Paulo - Brazil

^[2] Univ Fed Sao Paulo, Dept Hematol, Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Leukemia Research; v. 36, n. 1, p. 93-97, JAN 2012.
• Citações Web of Science: 2

Resumo

To evaluate the grading of fibrosis and immunohistochemical expression of MPL in bone marrow biopsies of ET and PMF. Fibrosis in bone marrow biopsies (BMBs) was evaluated according to the European Consensus for grading of fibrosis, according to reticulin proliferation. Immunohistochemical analysis was performed in samples from 18 ET and 38 PMF patients: 19 were classified as pre-fibrotic and 19 were classified as fibrotic according to the World Health Organization (WHO) criteria, by means of the MPL antibody. Six bone marrow donors' biopsies were used as controls. Average reticulin (p < 0.003) and MPL (p < 0.008) values differed significantly between the ET group and the pre-fibrotic stage PMF group. The MPL immunohistochemical expression may represent a new marker for differential diagnosis between ET and pre-fibrotic stage PMF. (C) 2011 Elsevier Ltd. All rights reserved. (AU)

• Processo FAPESP: 07/55948-8 - Comparacao da presenca de neoangiogenese entre portadores de policitemia vera jak2v617f, mielofibrose primaria e controles.
• Beneficiário: Maria de Lourdes Lopes Ferrari Chauffaille
• Modalidade de apoio: Auxílio à Pesquisa - Regular