Increased myeloperoxidase plasma levels in rheumatoid arthritis

Autor(es)

Sampaio Neves Fernandes, Raissa Maria ^[1] ; da Silva, Neusa Pereira ^[2] ; Sato, Emilia Inoue ^[2]

Afiliação do(s) autor(es)

^[1] Brazilian Soc Rheumatol, Piaui - Brazil

^[2] Univ Fed Sao Paulo, Div Rheumatol, BR-04023900 Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: RHEUMATOLOGY INTERNATIONAL; v. 32, n. 6, p. 1605-1609, JUN 2012.
• Citações Web of Science: 13

Resumo

High myeloperoxidase (MPO) serum levels have been shown in several inflammatory diseases, including rheumatoid arthritis (RA). However, the correlation between MPO levels and disease activity in RA patients is still controversial. The aim of the study was to determine MPO plasma levels in RA patients and to investigate potential correlations between MPO levels and disease activity and treatment. MPO plasma levels were measured by ELISA according the manufacturer's instructions. Disease activity was measured by DAS28 ESR and DAS28 CRP scores, and patients were classiWed into 4 groups: group 1 DAS28 < 2.6; group 2: 2.6 <= DAS28 <= 3.2; group 3: 3.2 < DAS28 <= 5.1 and group 4: DAS28 > 5.1. Rheumatoid factor (RF) was measured by latex agglutination test, and anti-cyclic citrullinated peptide (anti-CCP) antibodies were detected by ELISA with a commercial kit. Fifty-seven female RA patients (mean age: 46.02 +/- 13.47 years, mean disease duration: 115.77 +/- 99.44 months) and sixty gender- and age-paired healthy controls were included. Mean MPO plasma levels were significantly higher in patients than in controls (72.27 pM vs. 40.78 pM, P = 0.007). RF was found in 59.6% and anti-CCP in 80.7% of the RA patients. No significant difference in MPO levels was seen among the four RA disease activity groups. We did not find significant correlation between MPO levels and disease activity as measured by DAS28 score. In conclusion, we observed significantly higher MPO plasma levels in RA patients when compared to healthy controls. However, we did not find correlation between MPO plasma level and disease activity. (AU)

• Processo FAPESP: 04/11125-0 - Avaliacao dos niveis de mieloperoxidase no sangue periferico de mulheres com artrite reumatoide.
• Beneficiário: Emilia Inoue Sato
• Modalidade de apoio: Auxílio à Pesquisa - Regular