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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Expression profile of malignant and nonmalignant lesions of esophagus and stomach: differential activity of functional modules related to inflammation and lipid metabolism

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Autor(es):
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Gomes, Luciana I. ; Esteves, Gustavo H. ; Carvalho, Alex F. ; Cristo, Elier B. ; Hirata Júnior, Roberto ; Martins, Waleska K. ; Marques, Sarah M. ; Camargo, Luiz P. ; Brentani, Helena ; Pelosof, Adriane ; et al
Número total de Autores: 11
Tipo de documento: Artigo Científico
Fonte: Cancer Research; v. 65, n. 16, p. 7127-7136, Aug. 2005.
Área do conhecimento: Ciências da Saúde - Medicina
Assunto(s):Adenocarcinoma   Neoplasias gástricas   Neoplasias esofágicas
Resumo

Adenocarcinomas of stomach and esophagus are frequently associated with preceding inflammatory alterations of the normal mucosa. Whereas intestinal metaplasia of the gastric mucosa is associated with higher risk of malignization, Barrett's disease is a risk factor for adenocarcinoma of the esophagus. Barrett's disease is characterized by the substitution of the squamous mucosa of the esophagus by a columnar tissue classified histopathologically as intestinal metaplasia. Using cDNA microarrays, we determined the expression profile of normal gastric and esophageal mucosa as well as intestinal metaplasia and adenocarcinomas from both organs. Data were explored to define functional alterations related to the transformation from squamous to columnar epithelium and the malignant transformation from intestinal metaplasia to adenocarcinomas. Based on their expression profile, adenocarcinomas of the esophagus showed stronger correlation with intestinal metaplasia of the stomach than with Barrett's mucosa. Second, we identified two functional modules, lipid metabolism and cytokine, as being altered with higher statistical significance. Whereas the lipid metabolism module is active in samples representing intestinal metaplasia and inactive in adenocarcinomas, the cytokine module is inactive in samples representing normal esophagus and esophagitis. Using the concept of relevance networks, we determined the changes in linear correlation of genes pertaining to these two functional modules. Exploitation of the data presented herein will help in the precise molecular characterization of adenocarcinoma from the distal esophagus, avoiding the topographical and descriptive classification that is currently adopted, and help with the proper management of patients with Barrett's disease. (AU)

Processo FAPESP: 99/11962-9 - Fenômenos críticos em processos evolutivos e sistemas em equilíbrio
Beneficiário:Pablo Augusto Ferrari
Linha de fomento: Auxílio à Pesquisa - Temático
Processo FAPESP: 99/07390-0 - Cooperation for Analysis of Gene Expression - CAGE
Beneficiário:Hugo Aguirre Armelin
Linha de fomento: Auxílio à Pesquisa - Temático
Processo FAPESP: 98/14335-2 - Antonio Prudente Cancer Research Center
Beneficiário:Fernando Augusto Soares
Linha de fomento: Auxílio à Pesquisa - Centros de Pesquisa, Inovação e Difusão - CEPIDs