The Role of Pro-inflammatory and Anti-inflammatory Adipokines on Exercise-Induced Bronchospasm in Obese Adolescents Undergoing Treatment

Autor(es):Mostrar menos -

da Silva, Patricia Leao ^[1] ; de Mello, Marco Tulio ^[2] ; Cheik, Nadia Carla ^[3] ; Sanches, Priscila Lima ^[1] ; de Piano, Aline ^[1] ; Corgosinho, Flavia Campos ^[1] ; da Silveira Campos, Raquel Munhoz ^[1] ; Carnier, June ^[1] ; Inoue, Daniela ^[1] ; do Nascimento, Claudia M. O. ^{[1, 4]} ; Oyama, Lila M. ^[4] ; Tock, Lian ^[1] ; Tufik, Sergio ^[2] ; Damaso, Ana R. ^{[1, 5, 6]}

Afiliação do(s) autor(es)

^[1] Univ Fed Sao Paulo, Postgrad Program Nutr, BR-04020060 Sao Paulo - Brazil

^[2] Univ Fed Sao Paulo, Dept Psychobiol, BR-04020060 Sao Paulo - Brazil

^[3] Univ Fed Uberlandia, BR-38400 Uberlandia, MG - Brazil

^[4] Univ Fed Sao Paulo, Dept Physiol, BR-04020060 Sao Paulo - Brazil

^[5] Univ Fed Sao Paulo, Dept Biosci, BR-04020060 Sao Paulo - Brazil

^[6] Univ Fed Sao Paulo, Postgrad Program Interdisciplinary Hlth Sci, BR-04020060 Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Respiratory Care; v. 57, n. 4, p. 572-582, APR 2012.
• Citações Web of Science: 12

Resumo

BACKGROUND: Recent studies have demonstrated a greater prevalence in exercise-induced bronchospasm (EIB) in obese adolescents. However, the role of pro-/anti-inflammatory adipokines and the repercussions of obesity treatment on EIB need to be explored further. Therefore, the objective of this study was to evaluate the role of pro-/anti-inflammatory adipokines on EIB in obese adolescents evaluated after long-term interdisciplinary therapy. METHODS: Thirty-five post-pubertal obese adolescents, including 20 non-EIB (body mass index {[}BMI] 36 +/- 5 kg/m(2)) and 15 EIB (BMI 36 +/- 5 kg/m(2)), were enrolled in this study. Body composition was measured by plethysmography, using the BOD POD body composition system, and visceral fat was analyzed by ultrasound. Serum levels of adiponectin and leptin were analyzed. EIB and lung function were evaluated according to the American Thoracic Society criteria. Patients were recruited to a 1-year interdisciplinary intervention of weight loss, consisting of medical, nutritional, exercise, and psychological components. RESULTS: Anthropometrics and lung function variables improved significantly after the therapy in both groups. Furthermore we observed a reduction in EIB occurrence in obese adolescents after treatment. There was an increase in adiponectin levels and a reduction in leptin levels after the therapy. In addition, a low FEV1 value was a risk factor associated with EIB occurrence at baseline, and was correlated after treatment with changes in anthropometric and maximal O-2 consumption values as well as the adipokines profile. CONCLUSIONS: In the present study it was demonstrated that 1 year of interdisciplinary therapy decreased EIB frequency in obese adolescents, paralleled by an increase in lung function and improvement in pro-/anti-inflammatory adipokines. (AU)

• Processo FAPESP: 06/00684-3 - Fatores orexígenos, anorexígenos, pró e anti-inflamatórios: efeitos do programa multidisciplinar para redução da massa corporal em adolescentes obesos
• Beneficiário: Ana Raimunda Dâmaso
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 08/53069-0 - Efeitos do tratamento multidisciplinar em adolescentes obesos com esteatose hepática não alcoólica e sua relação com as adipocitocinas pró e anti-inflamatórias
• Beneficiário: Ana Raimunda Dâmaso
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 98/14303-3 - Center for Sleep Studies
• Beneficiário: Sergio Tufik
• Modalidade de apoio: Auxílio à Pesquisa - Centros de Pesquisa, Inovação e Difusão - CEPIDs