The Differential Clinical Impact of Human Coronavirus Species in Children With Cystic Fibrosis

Autor(es)

Ferreira da Silva Filho, Luiz Vicente Ribeiro ^{[1, 2]} ; Zerbinati, Rodrigo Melim ^[1] ; Tateno, Adriana Fumie ^[1] ; Boas, Lucy Vilas ^[1] ; de Almeida, Marina Buarque ^[2] ; Levi, Jose Eduardo ^[1] ; Drexler, Jan Felix ^[3] ; Drosten, Christian ^[3] ; Pannuti, Claudio Sergio ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Inst Med Trop Sao Paulo, Lab Virol LIMHC FMUSP, BR-05508 Sao Paulo - Brazil

^[2] Hosp Clin FMUSP, Inst Crianca, Sao Paulo - Brazil

^[3] Univ Bonn, Med Ctr, Inst Virol, Bonn - Germany

• Tipo de documento: Artigo Científico
• Fonte: Journal of Infectious Diseases; v. 206, n. 3, p. 384-388, AUG 1 2012.
• Citações Web of Science: 11

Resumo

We investigated the clinical impact of human coronaviruses (HCoV) OC43, 229E, HKU1 and NL63 in pediatric patients with cystic fibrosis (CF) during routine and exacerbation visits. A total of 408 nasopharyngeal aspirate samples were obtained from 103 patients over a 1-year period. Samples positive for HCoV were submitted for nucleotide sequencing to determine the species. Nineteen samples (4.65%) were positive for HCoV, of which 8 were positive for NL63, 6 for OC43, 4 for HKU1, and 1 for 229E. Identification of HCoV was not associated with an increased rate of respiratory exacerbations, but NL63-positive patients had higher exacerbation rates than patients who were positive for other HCoV species. (AU)

• Processo FAPESP: 05/01625-8 - Avaliação das infecções respiratórias virais em pacientes com fibrose cística
• Beneficiário: Luiz Vicente Ribeiro Ferreira da Silva Filho
• Modalidade de apoio: Auxílio à Pesquisa - Regular