| Full text | |
| Author(s): |
Ferreira da Silva Filho, Luiz Vicente Ribeiro
[1, 2]
;
Zerbinati, Rodrigo Melim
[1]
;
Tateno, Adriana Fumie
[1]
;
Boas, Lucy Vilas
[1]
;
de Almeida, Marina Buarque
[2]
;
Levi, Jose Eduardo
[1]
;
Drexler, Jan Felix
[3]
;
Drosten, Christian
[3]
;
Pannuti, Claudio Sergio
[1]
Total Authors: 9
|
| Affiliation: | [1] Univ Sao Paulo, Inst Med Trop Sao Paulo, Lab Virol LIMHC FMUSP, BR-05508 Sao Paulo - Brazil
[2] Hosp Clin FMUSP, Inst Crianca, Sao Paulo - Brazil
[3] Univ Bonn, Med Ctr, Inst Virol, Bonn - Germany
Total Affiliations: 3
|
| Document type: | Journal article |
| Source: | Journal of Infectious Diseases; v. 206, n. 3, p. 384-388, AUG 1 2012. |
| Web of Science Citations: | 11 |
| Abstract | |
We investigated the clinical impact of human coronaviruses (HCoV) OC43, 229E, HKU1 and NL63 in pediatric patients with cystic fibrosis (CF) during routine and exacerbation visits. A total of 408 nasopharyngeal aspirate samples were obtained from 103 patients over a 1-year period. Samples positive for HCoV were submitted for nucleotide sequencing to determine the species. Nineteen samples (4.65%) were positive for HCoV, of which 8 were positive for NL63, 6 for OC43, 4 for HKU1, and 1 for 229E. Identification of HCoV was not associated with an increased rate of respiratory exacerbations, but NL63-positive patients had higher exacerbation rates than patients who were positive for other HCoV species. (AU) | |