Acute exercise adjustments of cardiovascular autonomic control in diabetic rats

Autor(es)

Da Pureza, Demilto Yamagushi ^[1] ; Jorge, Luciana ^[2] ; Sanches, Iris Callado ^[3] ; Irigoyen, Maria-Claudia ^[2] ; De Souza, Romeu Rodrigues ^[1] ; De Angelis, Katia ^[3]

Afiliação do(s) autor(es)

^[1] Univ Sao Judas Tadeu, Human Movement Lab, Sao Paulo - Brazil

^[2] Univ Sao Paulo, Sch Med, Heart Inst InCor, Sao Paulo - Brazil

^[3] Nove de Julho Univ, Lab Translat Physiol, Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: MUSCLE & NERVE; v. 46, n. 1, p. 96-101, JUL 2012.
• Citações Web of Science: 1

Resumo

Introduction: We evaluated the role of cardiovascular autonomic changes in hemodynamics at rest and in response to exercise in streptozotocin-induced diabetic rats. Methods: Male Wistar rats were divided into nondiabetic (ND, n = 8) and diabetic (D, n = 8) groups. Arterial pressure signals were recorded in the basal state and after atropine or propranolol injections at rest, during exercise and during recovery. Results: At rest, vagal tonus was reduced in D (37 +/- 3 bpm) in comparison with the ND group (61 +/- 9 bpm). Heart rate during exercise was lower in D in relation to ND rats associated with reduced vagal withdrawal in the D group. The D rats had an increase in vagal tonus in the recovery period (49 +/- 6 bpm). Conclusions: Exercise-induced hemodynamic adjustment impairment in diabetic rats was associated with reduced cardiac vagal control. The vagal dysfunction was attenuated after aerobic exercise, reinforcing the positive role of this approach in the management of cardiovascular risk in diabetics. Muscle Nerve 46: 96101, 2012 (AU)

• Processo FAPESP: 07/58942-0 - Da bancada à clínica: desenvolvimento de biomarcadores como preditores da resposta à terapêutica e lesão de órgãos-alvo na hipertensão arterial sistemática
• Beneficiário: Eduardo Moacyr Krieger
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 07/57595-5 - Efeitos do treinamento físico no controle autônomo cardiovascular em fêmeas saudáveis e submetidas à privação dos hormônios ovarianos: papel do estresse oxidativo
• Beneficiário: Kátia de Angelis Lobo D Avila
• Modalidade de apoio: Auxílio à Pesquisa - Jovens Pesquisadores
• Processo FAPESP: 01/00009-0 - Estudo integrado da hipertensão arterial: caracterização molecular e funcional do sistema cardiovascular
• Beneficiário: Eduardo Moacyr Krieger
• Modalidade de apoio: Auxílio à Pesquisa - Temático