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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Acute exercise adjustments of cardiovascular autonomic control in diabetic rats

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Author(s):
Da Pureza, Demilto Yamagushi [1] ; Jorge, Luciana [2] ; Sanches, Iris Callado [3] ; Irigoyen, Maria-Claudia [2] ; De Souza, Romeu Rodrigues [1] ; De Angelis, Katia [3]
Total Authors: 6
Affiliation:
[1] Univ Sao Judas Tadeu, Human Movement Lab, Sao Paulo - Brazil
[2] Univ Sao Paulo, Sch Med, Heart Inst InCor, Sao Paulo - Brazil
[3] Nove de Julho Univ, Lab Translat Physiol, Sao Paulo - Brazil
Total Affiliations: 3
Document type: Journal article
Source: MUSCLE & NERVE; v. 46, n. 1, p. 96-101, JUL 2012.
Web of Science Citations: 1
Abstract

Introduction: We evaluated the role of cardiovascular autonomic changes in hemodynamics at rest and in response to exercise in streptozotocin-induced diabetic rats. Methods: Male Wistar rats were divided into nondiabetic (ND, n = 8) and diabetic (D, n = 8) groups. Arterial pressure signals were recorded in the basal state and after atropine or propranolol injections at rest, during exercise and during recovery. Results: At rest, vagal tonus was reduced in D (37 +/- 3 bpm) in comparison with the ND group (61 +/- 9 bpm). Heart rate during exercise was lower in D in relation to ND rats associated with reduced vagal withdrawal in the D group. The D rats had an increase in vagal tonus in the recovery period (49 +/- 6 bpm). Conclusions: Exercise-induced hemodynamic adjustment impairment in diabetic rats was associated with reduced cardiac vagal control. The vagal dysfunction was attenuated after aerobic exercise, reinforcing the positive role of this approach in the management of cardiovascular risk in diabetics. Muscle Nerve 46: 96101, 2012 (AU)

FAPESP's process: 07/58942-0 - From the bench to clinical trials: development of biomarkers as response predictors to therapy and target organs damage in systemic arterial hypertension
Grantee:Eduardo Moacyr Krieger
Support Opportunities: Research Projects - Thematic Grants
FAPESP's process: 01/00009-0 - An integrated approach for the dissection of primary hypertension: molecular and functional characterization of the cardiovascular system
Grantee:Eduardo Moacyr Krieger
Support Opportunities: Research Projects - Thematic Grants