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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

An overview of the therapeutic effects of leucine supplementation on skeletal muscle under atrophic conditions

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Autor(es):
Nicastro, Humberto [1] ; Artioli, Guilherme Giannini [1] ; Costa, Andre dos Santos [1] ; Solis, Marina Yazigi [1] ; da Luz, Claudia Ribeiro [1] ; Blachier, Francois [2] ; Lancha, Jr., Antonio Herbert [1]
Número total de Autores: 7
Afiliação do(s) autor(es):
[1] Univ Sao Paulo, Sch Phys Educ & Sports, Lab Appl Nutr & Metab, Sao Paulo - Brazil
[2] AgroParisTech, INRA, CRNH IdF, USC Nutr Physiol & Ingest Behav 914, Paris - France
Número total de Afiliações: 2
Tipo de documento: Artigo de Revisão
Fonte: Amino Acids; v. 40, n. 2, p. 287-300, FEB 2011.
Citações Web of Science: 39
Resumo

The characterization of the mechanisms underlying skeletal muscle atrophy under different conditions has been a constant focus of research. Among anti-atrophic therapies, amino acid supplementation, particularly with leucine, has received a lot of attention. Supplementation has been shown to have remarkable effects on muscle remodeling through protein turnover modulation. This may then impact physiological parameters related to muscle function, and even quality of life. In light of this, leucine supplementation could be a useful therapy for mitigating the atrophic effects of catabolic conditions. The purpose of this review is to present the major results of human studies evaluating the effects of leucine supplementation on structure and function of skeletal muscle in atrophic conditions such as muscle disuse, sarcopenia, and cancer. (AU)

Processo FAPESP: 09/02896-6 - Efeito do treinamento de força na modulação da resposta atrófica da musculatura esquelética induzida pelo uso de dexametasona
Beneficiário:Humberto Nicastro Silva
Modalidade de apoio: Bolsas no Brasil - Mestrado