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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

An overview of the therapeutic effects of leucine supplementation on skeletal muscle under atrophic conditions

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Author(s):
Nicastro, Humberto [1] ; Artioli, Guilherme Giannini [1] ; Costa, Andre dos Santos [1] ; Solis, Marina Yazigi [1] ; da Luz, Claudia Ribeiro [1] ; Blachier, Francois [2] ; Lancha, Jr., Antonio Herbert [1]
Total Authors: 7
Affiliation:
[1] Univ Sao Paulo, Sch Phys Educ & Sports, Lab Appl Nutr & Metab, Sao Paulo - Brazil
[2] AgroParisTech, INRA, CRNH IdF, USC Nutr Physiol & Ingest Behav 914, Paris - France
Total Affiliations: 2
Document type: Review article
Source: Amino Acids; v. 40, n. 2, p. 287-300, FEB 2011.
Web of Science Citations: 39
Abstract

The characterization of the mechanisms underlying skeletal muscle atrophy under different conditions has been a constant focus of research. Among anti-atrophic therapies, amino acid supplementation, particularly with leucine, has received a lot of attention. Supplementation has been shown to have remarkable effects on muscle remodeling through protein turnover modulation. This may then impact physiological parameters related to muscle function, and even quality of life. In light of this, leucine supplementation could be a useful therapy for mitigating the atrophic effects of catabolic conditions. The purpose of this review is to present the major results of human studies evaluating the effects of leucine supplementation on structure and function of skeletal muscle in atrophic conditions such as muscle disuse, sarcopenia, and cancer. (AU)

FAPESP's process: 09/02896-6 - Effect of resistance exercise on modulation of skeletal muscle atrophy dexamethasone-induced
Grantee:Humberto Nicastro Silva
Support Opportunities: Scholarships in Brazil - Master