Consumption of a Flaxseed-Rich Food Is Not More Effective Than a Placebo in Alleviating the Climacteric Symptoms of Postmenopausal Women

Autor(es)

Simbalista, Renee L. ^[1] ; Sauerbronn, Adolfo V. ^[2] ; Aldrighi, Jose M. ^[3] ; Areas, Jose A. G. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Fac Saude Publ, Dept Nutr, Sao Paulo - Brazil

^[2] Fundacao Zerbini, Sao Paulo - Brazil

^[3] Univ Sao Paulo, Fac Saude Publ, Dept Saude Materno Infantil, Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Journal of Nutrition; v. 140, n. 2, p. 293-297, FEB 2010.
• Citações Web of Science: 24

Resumo

Our objective in this work was to test the effects of daily intake of bread produced with partially defatted ground flaxseed on the climacteric symptoms and endometrial thickness of postmenopausal women. A double-blind, placebo-controlled, randomized clinical trial was performed with 38 women who had been postmenopausal for 1-10 y and consumed 2 slices of bread containing 25 g of flaxseed (46 mg lignans) or wheat bran (<1 mg lignans; control) every day for 12 consecutive weeks. The outcome variables were the daily number of hot flashes, the Kupperman Menopausal Index (KMI), and endometrial thickness. The plasma lipid profile (total cholesterol and HDL, LDL, and VLDL cholesterol fractions and triglycerides) and the hormones estradiol, follicle-stimulating hormone, thyroid-stimulating hormone, and free thyroxine also were measured. Food intake was evaluated by means of 2 24-hrecalls, before and after the treatment. Twenty patients in the study group and 18 in the control group completed the study. The general characteristics did not differ between the 2 groups at the start of the study. Both had significant, but similar, reductions in hot flashes and KMI after 3 mo of treatment. Moreover, endometrial thickness was not affected in either group. Our findings clearly show that although flaxseed is safe, its consumption at this level (46 mg lignans/d) is no more effective than placebo for reducing hot flashes and KMI. J. Nutr. 140: 293-297, 2010. (AU)

• Processo FAPESP: 07/07747-3 - Efeito de uma dieta rica em linhaça (Linum usitatissimum L.) no Câncer de Mama
• Beneficiário: José Alfredo Gomes Arêas
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 03/06717-2 - Efeitos de pao suplementados com semente de linhaca em mulheres no climaterio.
• Beneficiário: Renee Leao Simbalista
• Modalidade de apoio: Bolsas no Brasil - Doutorado