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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Consumption of a Flaxseed-Rich Food Is Not More Effective Than a Placebo in Alleviating the Climacteric Symptoms of Postmenopausal Women

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Author(s):
Simbalista, Renee L. [1] ; Sauerbronn, Adolfo V. [2] ; Aldrighi, Jose M. [3] ; Areas, Jose A. G. [1]
Total Authors: 4
Affiliation:
[1] Univ Sao Paulo, Fac Saude Publ, Dept Nutr, Sao Paulo - Brazil
[2] Fundacao Zerbini, Sao Paulo - Brazil
[3] Univ Sao Paulo, Fac Saude Publ, Dept Saude Materno Infantil, Sao Paulo - Brazil
Total Affiliations: 3
Document type: Journal article
Source: Journal of Nutrition; v. 140, n. 2, p. 293-297, FEB 2010.
Web of Science Citations: 24
Abstract

Our objective in this work was to test the effects of daily intake of bread produced with partially defatted ground flaxseed on the climacteric symptoms and endometrial thickness of postmenopausal women. A double-blind, placebo-controlled, randomized clinical trial was performed with 38 women who had been postmenopausal for 1-10 y and consumed 2 slices of bread containing 25 g of flaxseed (46 mg lignans) or wheat bran (<1 mg lignans; control) every day for 12 consecutive weeks. The outcome variables were the daily number of hot flashes, the Kupperman Menopausal Index (KMI), and endometrial thickness. The plasma lipid profile (total cholesterol and HDL, LDL, and VLDL cholesterol fractions and triglycerides) and the hormones estradiol, follicle-stimulating hormone, thyroid-stimulating hormone, and free thyroxine also were measured. Food intake was evaluated by means of 2 24-hrecalls, before and after the treatment. Twenty patients in the study group and 18 in the control group completed the study. The general characteristics did not differ between the 2 groups at the start of the study. Both had significant, but similar, reductions in hot flashes and KMI after 3 mo of treatment. Moreover, endometrial thickness was not affected in either group. Our findings clearly show that although flaxseed is safe, its consumption at this level (46 mg lignans/d) is no more effective than placebo for reducing hot flashes and KMI. J. Nutr. 140: 293-297, 2010. (AU)

FAPESP's process: 07/07747-3 - Effect of a diet rich in flaxseed (Linum usitatissimum L.) on Breast Cancer
Grantee:José Alfredo Gomes Arêas
Support Opportunities: Regular Research Grants