Heat stress impairs performance and induces intestinal inflammation in broiler chickens infected with Salmonella Enteritidis

Autor(es)

Quinteiro-Filho, W. M. ^[1] ; Gomes, A. V. S. ^[1] ; Pinheiro, M. L. ^[1] ; Ribeiro, A. ^[1] ; Ferraz-de-Paula, V. ^[1] ; Astolfi-Ferreira, C. S. ^[2] ; Ferreira, A. J. P. ^[2] ; Palermo-Neto, J. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Sch Vet Med, Dept Pathol, Neuroimmunomodulat Res Grp, BR-05508270 Sao Paulo - Brazil

^[2] Univ Sao Paulo, Sch Vet Med, Lab Ornithopathol, BR-05508270 Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: AVIAN PATHOLOGY; v. 41, n. 5, p. 421-427, 2012.
• Citações Web of Science: 61

Resumo

Stressful situations reduce the welfare, production indices and immune status of chickens. Salmonella spp. are a major zoonotic pathogens that annually cause over 1 billion infections worldwide. We therefore designed the current experiment to analyse the effects of 31 +/- 1 degrees C heat stress (HS) (from 35 to 41 days) on performance parameters, Salmonella invasion and small intestine integrity in broiler chickens infected with Salmonella Enteritidis. We observed that HS decreased body weight gain and feed intake. However, feed conversion was only increased when HS was combined with Salmonella Enteritidis infection. In addition, we observed an increase in serum corticosterone levels in all of the birds that were subjected to HS, showing a hypothalamus-pituitary-adrenal axis activation. Furthermore, mild acute multifocal lymphoplasmacytic enteritis, characterized by foci of heterophil infiltration in the duodenum, jejunum and ileum, was observed in the HS group. In contrast, similar but more evident enteritis was noted in the heat-stressed and Salmonella-infected group. In this group, moderate enteritis was observed in all parts of the small intestine. Lastly, we observed an increase in Salmonella counts in the spleens of the stressed and Salmonella-infected chickens. The combination of HS and Salmonella Enteritidis infection may therefore disrupt the intestinal barrier, which would allow pathogenic bacteria to migrate through the intestinal mucosa to the spleen and generate an inflammatory infiltrate in the gut, decreasing performance parameters. (AU)

• Processo FAPESP: 09/52487-5 - Efeitos do estresse por calor (31+-1grau C) sobre a expressão de HSP 70, a imunidade e integridade da mucosa intestinal e sua relação com a migração de Salmonela enteritidis para órgãos linfóides, fígado e pulmão de frangos de corte
• Beneficiário: Wanderley Moreno Quinteiro Filho
• Modalidade de apoio: Bolsas no Brasil - Doutorado