Oral tolerance and OVA-induced tolerogenic dendritic cells reduce the severity of collagen/ovalbumin-induced arthritis in mice

Autor(es)

Thome, Rodolfo ^[1] ; Romani Fernandes, Luis Gustavo ^[1] ; Mineiro, Marcela Franco ^[1] ; Simioni, Patricia Ucelli ^[1] ; Joazeiro, Paulo Pinto ^[2] ; da Silva Cunha Tamashiro, Wirla Maria ^[1]

Afiliação do(s) autor(es)

^[1] Univ Estadual Campinas, Dept Genet Evolut & Bioagents, Inst Biol, BR-13083970 Campinas, SP - Brazil

^[2] Univ Estadual Campinas, Dept Histol & Embryol, Inst Biol, BR-13083970 Campinas, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Cellular Immunology; v. 280, n. 1, p. 113-123, NOV 2012.
• Citações Web of Science: 13

Resumo

Dietary proteins play an important role in the regulation of systemic immune response, in a phenomenon known as oral tolerance (OT). To evaluate the effects of OT on a murine model of type II collagen (CII) plus ovalbumin (OVA)-induced arthritis (CIA), mice were fed with OVA either before or after CIA induction. OT significantly reduced the paw edema and synovial inflammation, as well as serum levels of anti-CII, the ex vivo proliferation and inflammatory cytokine production by spleen cells from CIA mice. The frequencies of Foxp3(+) and IL-10(+) cells were higher, whereas IFN gamma(+), cells and IL-17(+) cells were lower, among gated CD4(+) spleen T cells from tolerized CIA mice than in those from non-tolerized CIA mice. Adoptive transfer of tolerogenic dendritic cells (DCs) before CIA induction mimics the effects observed in the OT. We demonstrate here that bystander suppression induced by OT can modify the course of CIA and tolerogenic DCs play a role this phenomenon. (C) 2012 Elsevier Inc. All rights reserved. (AU)

• Processo FAPESP: 09/05891-5 - Artrite experimental induzida em camundongos por colágeno tipo II associado à ovalbumina: modulação pela tolerância oral
• Beneficiário: Wirla Maria da Silva Cunha Tamashiro
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 09/01838-2 - Modulação da artrite experimental induzida pela associação de colágeno tipo II e ovalbumina
• Beneficiário: Rodolfo Thomé
• Modalidade de apoio: Bolsas no Brasil - Mestrado