In vitro cytotoxic effects of Brazilian plant extracts on squamous cell carcinoma of the oral cavity

Autor(es)

Ozi, Joana Mattos ^[1] ; Suffredini, Ivana Barbosa ^[2] ; Paciencia, Mateus ^[3] ; Frana, Sergio Alexandre ^[2] ; Dib, Luciano Lauria ^[1]

Afiliação do(s) autor(es)

^[1] Univ Estadual Paulista, Grad Program Dent, Sao Paulo - Brazil

^[2] Univ Estadual Paulista, Ctr Res Biodivers, Extract Lab, Sao Paulo - Brazil

^[3] Univ Estadual Paulista, UNIP Herbarium, Ctr Res Biodivers, Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Brazilian Oral Research; v. 25, n. 6, p. 519-525, NOV-DEC 2011.
• Citações Web of Science: 10

Resumo

Squamous cell carcinoma (SCC) is the most prevalent cancer of the oral cavity and the fifth most prevalent of all malignancies in males. Many researchers have attempted to develop new treatments that will improve the prognosis of SCC patients. Over 20% of the world's biodiversity is located within the Brazilian forests, but little is known about the chemical and/or pharmacological potential of these plants. Certain extracts obtained from Amazon and Atlantic Forest plants have previously been shown to have cytotoxic activity against various cancers. The aim of this study was to screen these extracts for cytotoxic activity against oral SCC cells. The extracts were analyzed for activity against the KB-ADL#12 cell line at various concentrations up to a maximum dose of 100 µg/mL. Comparisons with a control group were performed using one-way ANOVA. Significant cytotoxicity was induced by the extracts obtained from the aerial parts of Picrolemma sprucei (Simaroubaceae), from the leaves and stems of Laetia suaveolens (Salicaceae), from the aerial parts of Abarema auriculata (Fabaceae-Mimosoideae) and from the stem of A. auriculata. (AU)

• Processo FAPESP: 08/58706-8 - Avaliação da atividade antitumoral, antibacteriana e ação sobre o sistema nervoso central e hormônios de extratos obtidos de plantas amazônicas e da Mata Atlântica
• Beneficiário: Ivana Barbosa Suffredini
• Modalidade de apoio: Auxílio à Pesquisa - Regular