Impairment on cardiovascular and autonomic adjustments to maximal isometric exercise tests in offspring of hypertensive parents

Autor(es)

Francica, Juliana V. ^[1] ; Heeren, Marcelo V. ^[1] ; Tubaldini, Marcio ^[1] ; Sartori, Michelle ^[2] ; Mostarda, Cristiano ^[2] ; Araujo, Rubens C. ^[1] ; Irigoyen, Maria-Claudia ^[2] ; De Angelis, Katia ^[3]

Afiliação do(s) autor(es)

^[1] Univ Sao Judas Tadeu, Human Movement Lab, Sao Paulo - Brazil

^[2] Univ Sao Paulo, Heart Inst InCor, Hypertens Unit, Sch Med, BR-05508 Sao Paulo - Brazil

^[3] Univ Nove de Julho, Translat Physiol Lab, BR-05001100 Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY; v. 20, n. 3, p. 480-485, JUN 2013.
• Citações Web of Science: 6

Resumo

The objective of the present study was to compare cardiovascular and autonomic responses to a mental stress test and to a maximal isometric exercise test between offspring of normotensive (ON, n = 10) and hypertensive parents (OH, n = 10). Subjects underwent a 3-min Stroop Color Word Test and a maximal isometric exercise test performed in an isokinetic dynamometer with continuous RR interval monitoring. At rest, arterial pressure and heart rate were similar between groups, but there was a significant reduction in total RR interval variance (ON: 5933 +/- 493 vs. OH: 2967 +/- 390 ms(2)) and an increase in low-high frequency components ratio of heart rate variability (ON: 2.3 +/- 0.4 vs. OH: 4.6 +/- 0.8) in OH group. In the first minute of the mental stress test and after both tests, the OH group presented increased heart rate as compared with the ON group. After both tests, only the ON group presented an increase in sympathetic component, thus reaching resting values similar to those of the OH group. Our data demonstrated increased resting cardiac sympathetic modulation in offspring of hypertensive parents at similar levels to that observed in offspring of normotensive parents after a mental stress test or a maximal isometric exercise test. Additionally, the exacerbated heart rate responses to these physiological tests in OH subjects may be associated with resting autonomic dysfunction, thus reinforcing these evaluations as important tools for detecting early dysfunctions in this genetically predisposed population. (AU)

• Processo FAPESP: 06/53738-3 - Ajustes cardiovasculares induzidos pelos exercícios resistidos em jovens com história familiar positiva de hipertensão
• Beneficiário: Juliana Valente Francica
• Modalidade de apoio: Bolsas no Brasil - Mestrado
• Processo FAPESP: 07/50001-2 - Comparacao do controle autonomico da circulacao entre ratos machos e femeas: estudo das adaptacoes ao treinamento fisico.
• Beneficiário: Michelle Sartori
• Modalidade de apoio: Bolsas no Brasil - Iniciação Científica
• Processo FAPESP: 06/53739-0 - Efeitos do treinamento físico em parâmetros hemodinâmicos e no estresse oxidativo em camundongos fêmeas LDL knockout submetidas à privação dos hormônios ovarianos
• Beneficiário: Marcelo Velloso Heeren
• Modalidade de apoio: Bolsas no Brasil - Mestrado