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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Impairment on cardiovascular and autonomic adjustments to maximal isometric exercise tests in offspring of hypertensive parents

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Author(s):
Francica, Juliana V. [1] ; Heeren, Marcelo V. [1] ; Tubaldini, Marcio [1] ; Sartori, Michelle [2] ; Mostarda, Cristiano [2] ; Araujo, Rubens C. [1] ; Irigoyen, Maria-Claudia [2] ; De Angelis, Katia [3]
Total Authors: 8
Affiliation:
[1] Univ Sao Judas Tadeu, Human Movement Lab, Sao Paulo - Brazil
[2] Univ Sao Paulo, Heart Inst InCor, Hypertens Unit, Sch Med, BR-05508 Sao Paulo - Brazil
[3] Univ Nove de Julho, Translat Physiol Lab, BR-05001100 Sao Paulo - Brazil
Total Affiliations: 3
Document type: Journal article
Source: EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY; v. 20, n. 3, p. 480-485, JUN 2013.
Web of Science Citations: 6
Abstract

The objective of the present study was to compare cardiovascular and autonomic responses to a mental stress test and to a maximal isometric exercise test between offspring of normotensive (ON, n = 10) and hypertensive parents (OH, n = 10). Subjects underwent a 3-min Stroop Color Word Test and a maximal isometric exercise test performed in an isokinetic dynamometer with continuous RR interval monitoring. At rest, arterial pressure and heart rate were similar between groups, but there was a significant reduction in total RR interval variance (ON: 5933 +/- 493 vs. OH: 2967 +/- 390 ms(2)) and an increase in low-high frequency components ratio of heart rate variability (ON: 2.3 +/- 0.4 vs. OH: 4.6 +/- 0.8) in OH group. In the first minute of the mental stress test and after both tests, the OH group presented increased heart rate as compared with the ON group. After both tests, only the ON group presented an increase in sympathetic component, thus reaching resting values similar to those of the OH group. Our data demonstrated increased resting cardiac sympathetic modulation in offspring of hypertensive parents at similar levels to that observed in offspring of normotensive parents after a mental stress test or a maximal isometric exercise test. Additionally, the exacerbated heart rate responses to these physiological tests in OH subjects may be associated with resting autonomic dysfunction, thus reinforcing these evaluations as important tools for detecting early dysfunctions in this genetically predisposed population. (AU)