ZDHHC8 gene may play a role in cortical volumes of patients with schizophrenia

Autor(es):Mostrar menos -

Ota, Vanessa K. ^{[1, 2]} ; Gadelha, Ary ^{[3, 2]} ; Assuncao, Idaiane B. ^[2] ; Santoro, Marcos L. ^{[1, 2]} ; Christofolini, Denise M. ^[4] ; Bellucco, Fernanda T. ^[1] ; Santos-Filho, Airton F. ^[3] ; Ottoni, Gustavo L. ^[5] ; Lara, Diogo R. ^[5] ; Mari, Jair J. ^[3] ; Melaragno, Maria I. ^[1] ; Smith, Marilia A. C. ^[1] ; Bressan, Rodrigo A. ^{[3, 2]} ; Belangero, Sintia I. ^{[1, 3, 2]} ; Jackowski, Andrea P. ^{[3, 2]}

Afiliação do(s) autor(es)

^[1] Univ Fed Sao Paulo UNIFESP, Dept Morfol & Genet, Disciplina Genet, BR-04023900 Sao Paulo - Brazil

^[2] Univ Fed Sao Paulo UNIFESP, Dept Psiquiatria, Lab Interdisciplinar Neurociencias Clin LiNC, Sao Paulo - Brazil

^[3] Univ Fed Sao Paulo UNIFESP, Dept Psiquiatria, Sao Paulo - Brazil

^[4] FMABC, Dept Obstet & Ginecol, Disciplina Genet & Reprod Humana, Sao Paulo - Brazil

^[5] Pontificia Univ Rio Grande Sul PUCRS, Fac Biociencias, Porto Alegre, RS - Brazil

• Tipo de documento: Artigo Científico
• Fonte: SCHIZOPHRENIA RESEARCH; v. 145, n. 1-3, p. 33-35, APR 2013.
• Citações Web of Science: 9

Resumo

ZDHHC8 rs175174 polymorphism is located in 22q11.2 region and its role in brain volume has not been fully addressed. A total of 282 schizophrenia patients and 379 controls were genotyped. A sample of 138 patients underwent brain MRI scan. No association was found between schizophrenia and genotypes. Nevertheless, GG-genotype carriers presented gray matter volume (GMV) reduction in frontal lobe compared to A-allele carriers, and cerebellar hemispheres GMV reductions were found in G-allele carriers compared to AA-genotype. Moreover, A-allele carriers presented posterior brain GMV reductions when compared to GG-genotype. These data suggest that ZDHHC8 may play a role in cortical volumes. (C) 2013 Elsevier B. V. All rights reserved. (AU)

• Processo FAPESP: 11/00030-1 - Estudo de associação de genes do sistema endocanabinóide e esquizofrenia
• Beneficiário: Síntia Iole Nogueira Belangero
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 07/58736-1 - Investigação da região cromossômica 22q11.2 na patogênese de alterações cardíacas e da esquizofrenia
• Beneficiário: Marilia de Arruda Cardoso Smith
• Modalidade de apoio: Auxílio à Pesquisa - Regular