Advanced search
Start date
Betweenand
Related content
(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

ZDHHC8 gene may play a role in cortical volumes of patients with schizophrenia

Full text
Author(s):
Show less -
Ota, Vanessa K. [1, 2] ; Gadelha, Ary [3, 2] ; Assuncao, Idaiane B. [2] ; Santoro, Marcos L. [1, 2] ; Christofolini, Denise M. [4] ; Bellucco, Fernanda T. [1] ; Santos-Filho, Airton F. [3] ; Ottoni, Gustavo L. [5] ; Lara, Diogo R. [5] ; Mari, Jair J. [3] ; Melaragno, Maria I. [1] ; Smith, Marilia A. C. [1] ; Bressan, Rodrigo A. [3, 2] ; Belangero, Sintia I. [1, 3, 2] ; Jackowski, Andrea P. [3, 2]
Total Authors: 15
Affiliation:
[1] Univ Fed Sao Paulo UNIFESP, Dept Morfol & Genet, Disciplina Genet, BR-04023900 Sao Paulo - Brazil
[2] Univ Fed Sao Paulo UNIFESP, Dept Psiquiatria, Lab Interdisciplinar Neurociencias Clin LiNC, Sao Paulo - Brazil
[3] Univ Fed Sao Paulo UNIFESP, Dept Psiquiatria, Sao Paulo - Brazil
[4] FMABC, Dept Obstet & Ginecol, Disciplina Genet & Reprod Humana, Sao Paulo - Brazil
[5] Pontificia Univ Rio Grande Sul PUCRS, Fac Biociencias, Porto Alegre, RS - Brazil
Total Affiliations: 5
Document type: Journal article
Source: SCHIZOPHRENIA RESEARCH; v. 145, n. 1-3, p. 33-35, APR 2013.
Web of Science Citations: 9
Abstract

ZDHHC8 rs175174 polymorphism is located in 22q11.2 region and its role in brain volume has not been fully addressed. A total of 282 schizophrenia patients and 379 controls were genotyped. A sample of 138 patients underwent brain MRI scan. No association was found between schizophrenia and genotypes. Nevertheless, GG-genotype carriers presented gray matter volume (GMV) reduction in frontal lobe compared to A-allele carriers, and cerebellar hemispheres GMV reductions were found in G-allele carriers compared to AA-genotype. Moreover, A-allele carriers presented posterior brain GMV reductions when compared to GG-genotype. These data suggest that ZDHHC8 may play a role in cortical volumes. (C) 2013 Elsevier B. V. All rights reserved. (AU)

FAPESP's process: 11/00030-1 - Association study of endocannabinoid system and schizophrenia
Grantee:Síntia Iole Nogueira Belangero
Support Opportunities: Regular Research Grants
FAPESP's process: 07/58736-1 - Investigation of 22q11.2 chromosomal region in the pathogenesis of cardiac alterations and schizophrenia
Grantee:Marilia de Arruda Cardoso Smith
Support Opportunities: Regular Research Grants