Does plasma HDL-C concentration interact with whole-body cholesterol metabolism?

Autor(es)

Leanca, C. C. ^[1] ; Nunes, V. S. ^[1] ; Nakandakare, E. R. ^[1] ; de Faria, E. C. ^[2] ; Quintao, E. C. R. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Fac Med Sci, Div Hosp Clin, Lipids Lab Endocrinol & Metab LIM 10, BR-01246000 Sao Paulo - Brazil

^[2] State Univ Campinas UNICAMP, Sch Med Sci, Dept Clin Pathol, BR-13083970 Sao Paulo - Brazil

• Tipo de documento: Artigo de Revisão
• Fonte: NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES; v. 23, n. 4, p. 279-284, APR 2013.
• Citações Web of Science: 3

Resumo

This review examines the interactions between plasma high density lipoprotein (HDL) metabolism and whole-body cholesterol economy. More specifically, this review addresses three questions: 1) does plasma HDL-C concentration correlate with the parameters of whole-body cholesterol metabolism? 2) Do variations in cholesterol metabolism interfere with plasma HDL-C concentrations? 3) Are the markers of cholesterol synthesis and intestinal absorption specifically under the control of plasma HDL? The following answers were provided to each question, respectively: 1) plasma HDL influences whole-body cholesterol synthesis rate but the evidence that HDL modifies the total amount of cholesterol absorbed by the intestine is not clearly supported by present investigations; 2) there are suggestions that changes in whole body cholesterol metabolism rates do not interfere with plasma HDL-C concentrations; 3) markers of cholesterol synthesis and absorption may specifically be controlled by plasma HDL-C concentrations regarding the genetic causes of extremely low HDL-C concentrations, although within the general population plasma HDL-C concentration is likely ascribed to insulin resistance or diabetes mellitus. (C) 2012 Elsevier B.V. All rights reserved. (AU)

• Processo FAPESP: 06/60585-9 - Relação da concentração de HDL colesterol no plasma com o metabolismo corpóreo de colesterol e em monócitos no ser humano
• Beneficiário: Eder Carlos Rocha Quintão
• Modalidade de apoio: Auxílio à Pesquisa - Temático