Medial prefrontal cortex N-methyl-D-aspartate receptor/nitric oxide/cyclic guanosine monophosphate pathway modulates both tachycardic and bradycardic baroreflex responses

Autor(es)

Ferreira-Junior, Nilson C. ^[1] ; Fedoce, Alessandra G. ^[1] ; Alves, Fernando H. F. ^[1] ; Resstel, Leonardo B. M. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Sch Med Ribeirao Preto, Dept Pharmacol, BR-14049900 Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Journal of Neuroscience Research; v. 91, n. 10, p. 1338-1348, OCT 2013.
• Citações Web of Science: 9

Resumo

Neural reflex mechanisms, such as the baroreflex, are involved in regulating cardiovascular system activity. Previous results showed that the ventral portion of the medial prefrontal cortex (vMPFC) is involved in modulation only of the cardiac baroreflex bradycardic component. Moreover, vMPFC N-methyl-D-aspartate (NMDA) receptors modulate the bradycardia baroreflex, but the baroreflex tachycardic component has not been investigated. Furthermore, glutamatergic neurotransmission into the vMPFC is involved in activation of the cardiac sympathetic and parasympathetic nervous system. Finally, it has been demonstrated that glutamatergic neurotransmission into the vMPFC can be modulated by the endocannabinoid system and that activation of the CB1 cannabinoid receptor by anandamide, an endocannabinoid, can decrease both cardiac baroreflex bradycardic and tachycardic responses. Thus, there is the possibility that glutamatergic neurotransmission into the vMPFC does not modulate only the cardiac bradycardic component of the baroreflex. Therefore, the present study investigated whether glutamatergic neurotransmission into the vMPFC modulates both cardiac baroreflex bradycardic and tachycardic responses. We found that vMPFC bilateral microinjection of the NMDA receptor antagonist AP7 (4 nmol/200 nl), of a selective inhibitor of neuronal nitric oxide (NO) synthase N-propyl (0.08 nmol/200 nl), of the NO scavenger carboxy-PTIO (2 nmol/200 nl), or of the NO-sensitive guanylate cyclase ODQ (2 nmol/200 nl) decreased the baroreflex activity in unanesthetized rats. Therefore, our results demonstrate the participation of NMDA receptors, production of NO, and activation of guanylate cyclase in the vMPFC in the modulation of both cardiac baroreflex bradycardic and tachycardic responses. (c) 2013 Wiley Periodicals, Inc. (AU)

• Processo FAPESP: 11/07332-3 - Estudo do envolvimento do hipocampo dorsal de ratos nas respostas comportamentais e autonômicas associadas a reações de defesa: uma possível via receptores NMDA/óxido nítrico e endocanabinóides
• Beneficiário: Leonardo Resstel Barbosa Moraes
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 11/20762-7 - Avaliação da participação do estresse oxidativo/nitrosativo induzidos pelo estresse de restrição na modulação da resposta emocional condicionada
• Beneficiário: Alessandra das Graças Fedoce
• Modalidade de apoio: Bolsas no Brasil - Doutorado
• Processo FAPESP: 10/09462-9 - Estudo dos mecanismos periféricos envolvidos na resposta cardiovascular de ratos durante a sepse: possível participação do sistema endocanabinóide
• Beneficiário: Fernando Henrique Ferrari Alves
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 11/19494-8 - Envolvimento do hipocampo dorsal na modulação da atividade barorreflexa cardíaca: participação dos receptores NMDA, CB1, TRPV1, muscarínicos e do óxido nítrico.
• Beneficiário: Nilson Carlos Ferreira Junior
• Modalidade de apoio: Bolsas no Brasil - Doutorado