Excess androgen during perinatal life alters steroid receptor expression, apoptosis, and cell proliferation in the uteri of the offspring

Autor(es)

Guerra, Marina T. ^[1] ; Sanabria, Marciana ^[2] ; Grossman, Gail ^{[3, 4]} ; Petrusz, Peter ^{[3, 4]} ; Kempinas, Wilma de Grava ^[2]

Afiliação do(s) autor(es)

^[1] Univ Estadual Campinas, UNICAMP, Inst Biol, Grad Program Cell & Struct Biol, Campinas, SP - Brazil

^[2] Univ Estadual Paulista, Inst Biosci, Dept Morphol, UNESP, Botucatu, SP - Brazil

^[3] Univ N Carolina, Dept Cell & Dev Biol, Chapel Hill, NC - USA

^[4] Univ N Carolina, Labs Reprod Biol, Chapel Hill, NC - USA

• Tipo de documento: Artigo Científico
• Fonte: REPRODUCTIVE TOXICOLOGY; v. 40, p. 1-7, SEP 2013.
• Citações Web of Science: 8

Resumo

Exposure to environmental chemicals may contribute to reproductive disorders, especially when it occurs in critical periods of development. The female reproductive system can be a target for androgens derived from environmental contaminants or pathological conditions. The purpose of this study was to assess the long-term effects of androgens on uterine tissue after maternal exposure limited to the time of gestation and lactation. Pregnant Wistar rats were treated with testosterone propionate (TP) at 0.05 mg/kg, 0.1 mg/kg, 0.2 mg/kg or corn oil (vehicle), s.c., from gestational day 12 until the end of lactation. The results show changes in the pattern of expression of receptors for estrogen, progesterone, and androgen at all doses tested, and decreases in both apoptosis and cell proliferation indices at 0.1 and 0.2 mg/kg. We conclude that early TP exposure, under these experimental conditions, causes changes in cellular and molecular parameters that are essential for normal uterine function in the adult. (C) 2013 Elsevier Inc. All rights reserved. (AU)

• Processo FAPESP: 09/00352-9 - Estrutura do trato genital e função reprodutiva de ratas expostas a propionato de testosterona in utero e durante a lactação
• Beneficiário: Marina Trevizan Guerra
• Modalidade de apoio: Bolsas no Brasil - Doutorado