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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

A differential diagnosis of inherited endocrine tumors and their tumor counterparts

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Autor(es):
Toledo, Sergio P. A. [1] ; Lourenco, Jr., Delmar M. [1] ; Toledo, Rodrigo A. [2]
Número total de Autores: 3
Afiliação do(s) autor(es):
[1] Univ Sao Paulo, Fac Med, Endocrine Genet Unit LIM 25, Div Endocrinol, Sao Paulo - Brazil
[2] Univ Texas Hlth Sci Ctr San Antonio, San Antonio, TX 78229 - USA
Número total de Afiliações: 2
Tipo de documento: Artigo de Revisão
Fonte: Clinics; v. 68, n. 7, p. 1039-1056, 2013.
Citações Web of Science: 8
Resumo

Inherited endocrine tumors have been increasingly recognized in clinical practice, although some difficulties still exist in differentiating these conditions from their sporadic endocrine tumor counterparts. Here, we list the 12 main topics that could add helpful information and clues for performing an early differential diagnosis to distinguish between these conditions. The early diagnosis of patients with inherited endocrine tumors may be performed either clinically or by mutation analysis in at-risk individuals. Early detection usually has a large impact in tumor management, allowing preventive clinical or surgical therapy in most cases. Advice for the clinical and surgical management of inherited endocrine tumors is also discussed. In addition, recent clinical and genetic advances for 17 different forms of inherited endocrine tumors are briefly reviewed. (AU)

Processo FAPESP: 09/15386-6 - Análise dos genes CDKN1A, CDKN1B, CDKN2B e CDKN2C, nas Neoplasias Endócrinas Múltiplas tipo 1 e 2
Beneficiário:Rodrigo de Almeida Toledo
Linha de fomento: Bolsas no Brasil - Pós-Doutorado
Processo FAPESP: 08/58552-0 - Neoplasia endócrina múltipla tipo 1 (NEM1): análises de mutações germinativas nos genes supressores de tumor MEN1, CDKN1B/p27Kip1 e AIP; estudo de expressão gênica e proteica e; caracterização clínica
Beneficiário:Delmar Muniz Lourenço Jr
Linha de fomento: Bolsas no Brasil - Pós-Doutorado