Oxidized low-density lipoprotein, matrix-metalloproteinase-8 and carotid atherosclerosis in spinal cord injured subjects

Autor(es):Mostrar menos -

Paim, Layde R. ^[1] ; Schreiber, Roberto ^[1] ; Matos-Souza, Jose R. ^[1] ; Silva, Anselmo A. ^[2] ; Campos, Luis F. ^[2] ; Azevedo, Eliza R. ^[3] ; Alonso, Karina ^[3] ; de Rossi, Guilherme ^[1] ; Etchebehere, Mauricio ^[3] ; Gorla, Jose I. ^[2] ; Cliquet, Jr., Alberto ^{[4, 3]} ; Nadruz, Jr., Wilson ^[1]

Afiliação do(s) autor(es)

^[1] Univ Estadual Campinas, Sch Med Sci, Dept Internal Med, BR-13081970 Campinas, SP - Brazil

^[2] Univ Estadual Campinas, Sch Phys Educ, BR-13081970 Campinas, SP - Brazil

^[3] Univ Estadual Campinas, Sch Med Sci, Dept Orthopaed, BR-13081970 Campinas, SP - Brazil

^[4] Univ Sao Paulo, Dept Elect Engn, Sao Carlos, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: ATHEROSCLEROSIS; v. 231, n. 2, p. 341-345, DEC 2013.
• Citações Web of Science: 11

Resumo

Objective: Previous reports have indicated that subjects with chronic spinal cord injury (SCI) exhibit increased cardiovascular risk compared to able-bodied individuals. This study investigated the relationship between plasmatic oxidized low-density lipoprotein (OxLDL), matrix metalloproteinases (MMPs) and tissue inhibitors of MMPs (TIMPs) levels and vascular remodeling in SCI subjects and the role of physical activity in this regard. Methods: We studied 42 men with chronic (>= 2 years) SCI {[}18 sedentary (S-SCI) and 24 physically active (PA-SCI)] and 16 able-bodied men by clinical, anthropometric, laboratory, and carotid intima-media thickness (IMT) analysis. All enrolled subjects were normotensive, non-diabetics, non-smokers and normolipemic. Plasmatic OxLDL, MMP-2, MMP-8, MMP-9, TIMP-1 and TIMP-2 levels were determined by enzyme-linked immunosorbent assay. Results: Carotid IMT, IMT/diameter ratio and OxLDL levels of PA-SCI and able-bodied subjects were statistically similar. Conversely, S-SCI subjects exhibited higher IMT, IMT/diameter ratio and OxLDL levels compared to PA-SCI (p < 0.01, p < 0.001 and p = 0.01, respectively) and able-bodied (p < 0.001 for all) individuals. Results of bivariate correlation analysis including all injured subjects showed that carotid IMT and IMT/diameter ratio only correlated with OxLDL, MMP-8 and MMP-8/TIMP-1 ratio. Further stepwise regression analysis adjusted for the presence or not of physical activity and age showed that OxLDL was associated with carotid IMT and IMT/diameter ratio, while MMP-8 was associated with IMT/diameter ratio in SCI individuals. Conclusions: Plasmatic OxLDL and MMP-8 levels are associated with carotid atherosclerosis and there is an interaction among physical inactivity, atherosclerosis and OxLDL in SCI individuals. (C) 2013 Elsevier Ireland Ltd. All rights reserved. (AU)

• Processo FAPESP: 10/16252-0 - Mecanismos envolvidos no aumento do risco cardiovascular em portadores de lesão da medula espinhal
• Beneficiário: Wilson Nadruz Junior
• Modalidade de apoio: Auxílio à Pesquisa - Regular