| Full text | |
| Author(s): Show less - |
Paim, Layde R.
[1]
;
Schreiber, Roberto
[1]
;
Matos-Souza, Jose R.
[1]
;
Silva, Anselmo A.
[2]
;
Campos, Luis F.
[2]
;
Azevedo, Eliza R.
[3]
;
Alonso, Karina
[3]
;
de Rossi, Guilherme
[1]
;
Etchebehere, Mauricio
[3]
;
Gorla, Jose I.
[2]
;
Cliquet, Jr., Alberto
[4, 3]
;
Nadruz, Jr., Wilson
[1]
Total Authors: 12
|
| Affiliation: | [1] Univ Estadual Campinas, Sch Med Sci, Dept Internal Med, BR-13081970 Campinas, SP - Brazil
[2] Univ Estadual Campinas, Sch Phys Educ, BR-13081970 Campinas, SP - Brazil
[3] Univ Estadual Campinas, Sch Med Sci, Dept Orthopaed, BR-13081970 Campinas, SP - Brazil
[4] Univ Sao Paulo, Dept Elect Engn, Sao Carlos, SP - Brazil
Total Affiliations: 4
|
| Document type: | Journal article |
| Source: | ATHEROSCLEROSIS; v. 231, n. 2, p. 341-345, DEC 2013. |
| Web of Science Citations: | 11 |
| Abstract | |
Objective: Previous reports have indicated that subjects with chronic spinal cord injury (SCI) exhibit increased cardiovascular risk compared to able-bodied individuals. This study investigated the relationship between plasmatic oxidized low-density lipoprotein (OxLDL), matrix metalloproteinases (MMPs) and tissue inhibitors of MMPs (TIMPs) levels and vascular remodeling in SCI subjects and the role of physical activity in this regard. Methods: We studied 42 men with chronic (>= 2 years) SCI {[}18 sedentary (S-SCI) and 24 physically active (PA-SCI)] and 16 able-bodied men by clinical, anthropometric, laboratory, and carotid intima-media thickness (IMT) analysis. All enrolled subjects were normotensive, non-diabetics, non-smokers and normolipemic. Plasmatic OxLDL, MMP-2, MMP-8, MMP-9, TIMP-1 and TIMP-2 levels were determined by enzyme-linked immunosorbent assay. Results: Carotid IMT, IMT/diameter ratio and OxLDL levels of PA-SCI and able-bodied subjects were statistically similar. Conversely, S-SCI subjects exhibited higher IMT, IMT/diameter ratio and OxLDL levels compared to PA-SCI (p < 0.01, p < 0.001 and p = 0.01, respectively) and able-bodied (p < 0.001 for all) individuals. Results of bivariate correlation analysis including all injured subjects showed that carotid IMT and IMT/diameter ratio only correlated with OxLDL, MMP-8 and MMP-8/TIMP-1 ratio. Further stepwise regression analysis adjusted for the presence or not of physical activity and age showed that OxLDL was associated with carotid IMT and IMT/diameter ratio, while MMP-8 was associated with IMT/diameter ratio in SCI individuals. Conclusions: Plasmatic OxLDL and MMP-8 levels are associated with carotid atherosclerosis and there is an interaction among physical inactivity, atherosclerosis and OxLDL in SCI individuals. (C) 2013 Elsevier Ireland Ltd. All rights reserved. (AU) | |
| FAPESP's process: | 10/16252-0 - Mechanisms related to increased cardiovascular risk in spinal cord injury subjects |
| Grantee: | Wilson Nadruz Junior |
| Support Opportunities: | Regular Research Grants |