Lycopene supplementation modulates plasma concentrations and epididymal adipose tissue mRNA of leptin, resistin and IL-6 in diet-induced obese rats

Autor(es)

Melo Luvizotto, Renata de Azevedo ^{[1, 2]} ; Nascimento, Andre F. ^{[1, 2]} ; Imaizumi, Erika ^[1] ; Pierine, Damiana T. ^{[2, 3]} ; Conde, Sandro J. ^[1] ; Correa, Camila R. ^[3] ; Yeum, Kyung-Jin ^{[2, 4]} ; Ferreira, Ana Lucia A. ^[1]

Afiliação do(s) autor(es)

^[1] Sao Paulo State Univ, UNESP, Botucatu Med Sch, Internal Med Lab, Dept Internal Med, BR-18618970 Botucatu, SP - Brazil

^[2] Tufts Univ, Human Nutr Res Ctr Aging, Jean Mayer United States Dept Agr, Boston, MA 02111 - USA

^[3] Sao Paulo State Univ, UNESP, Botucatu Med Sch, Dept Pathol, BR-18618970 Botucatu, SP - Brazil

^[4] Konkuk Univ, Coll Biomed & Hlth Sci, Seoul - South Korea

• Tipo de documento: Artigo Científico
• Fonte: BRITISH JOURNAL OF NUTRITION; v. 110, n. 10, p. 1803-1809, NOV 28 2013.
• Citações Web of Science: 27

Resumo

Obesity is characterised by chronic low-grade inflammation, and lycopene has been reported to display anti-inflammatory effects. However, it is not clear whether lycopene supplementation modulates adipokine levels in vivo in obesity. To determine whether lycopene supplementation can regulate adipokine expression in obesity, male Wistar rats were randomly assigned to receive a control diet (C, n 6) or a hyperenergetic diet (DIO, n 12) for 6 weeks. After this period, the DIO animals were randomised into two groups: DIO (n 6) and DIO supplemented with lycopene (DIO + L, n 6). The animals received maize oil (C and DIO) or lycopene (DIO + L, 10 mg/kg body weight (BW) per d) by oral administration for a 6-week period. The animals were then killed by decapitation, and blood samples and epididymal adipose tissue were collected for hormonal determination and gene expression evaluation (IL-6, monocyte chemoattractant protein-1 (MCP-1), TNF-alpha, leptin and resistin). There was no detectable lycopene in the plasma of the C and DIO groups. However, the mean lycopene plasma concentration was 24 nmol in the DIO + L group. Although lycopene supplementation did not affect BW or adiposity, it significantly decreased leptin, resistin and IL-6 gene expression in epididymal adipose tissue and plasma concentrations. Also, it significantly reduced the gene expression of MCP-1 in epididymal adipose tissue. Lycopene affects adipokines by reducing leptin, resistin and plasma IL-6 levels. These data suggest that lycopene may be an effective strategy in reducing inflammation in obesity. (AU)

• Processo FAPESP: 11/22786-0 - Influência do licopeno sobre marcadores de estresse oxidativo no tecido adiposo de ratos obesos
• Beneficiário: Renata de Azevedo Melo Luvizotto Nascimento
• Modalidade de apoio: Bolsas no Exterior - Estágio de Pesquisa - Pós-Doutorado
• Processo FAPESP: 10/19746-4 - Efeito da suplementação com licopeno em modelo experimental de obesidade induzida por dieta
• Beneficiário: Renata de Azevedo Melo Luvizotto Nascimento
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 11/19847-8 - Efeito do licopeno sobre o estresse oxidativo, processo inflamatório e resistência à insulina no tecido adiposo de animais com sobrecarga nutricional
• Beneficiário: Érika Imaizumi
• Modalidade de apoio: Bolsas no Brasil - Iniciação Científica
• Processo FAPESP: 10/06100-9 - Efeito da suplementação com licopeno na obesidade em modelo experimental com ratos Zucker
• Beneficiário: Ana Lucia do Anjos Ferreira
• Modalidade de apoio: Auxílio à Pesquisa - Regular