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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Lycopene supplementation modulates plasma concentrations and epididymal adipose tissue mRNA of leptin, resistin and IL-6 in diet-induced obese rats

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Author(s):
Melo Luvizotto, Renata de Azevedo [1, 2] ; Nascimento, Andre F. [1, 2] ; Imaizumi, Erika [1] ; Pierine, Damiana T. [2, 3] ; Conde, Sandro J. [1] ; Correa, Camila R. [3] ; Yeum, Kyung-Jin [2, 4] ; Ferreira, Ana Lucia A. [1]
Total Authors: 8
Affiliation:
[1] Sao Paulo State Univ, UNESP, Botucatu Med Sch, Internal Med Lab, Dept Internal Med, BR-18618970 Botucatu, SP - Brazil
[2] Tufts Univ, Human Nutr Res Ctr Aging, Jean Mayer United States Dept Agr, Boston, MA 02111 - USA
[3] Sao Paulo State Univ, UNESP, Botucatu Med Sch, Dept Pathol, BR-18618970 Botucatu, SP - Brazil
[4] Konkuk Univ, Coll Biomed & Hlth Sci, Seoul - South Korea
Total Affiliations: 4
Document type: Journal article
Source: BRITISH JOURNAL OF NUTRITION; v. 110, n. 10, p. 1803-1809, NOV 28 2013.
Web of Science Citations: 27
Abstract

Obesity is characterised by chronic low-grade inflammation, and lycopene has been reported to display anti-inflammatory effects. However, it is not clear whether lycopene supplementation modulates adipokine levels in vivo in obesity. To determine whether lycopene supplementation can regulate adipokine expression in obesity, male Wistar rats were randomly assigned to receive a control diet (C, n 6) or a hyperenergetic diet (DIO, n 12) for 6 weeks. After this period, the DIO animals were randomised into two groups: DIO (n 6) and DIO supplemented with lycopene (DIO + L, n 6). The animals received maize oil (C and DIO) or lycopene (DIO + L, 10 mg/kg body weight (BW) per d) by oral administration for a 6-week period. The animals were then killed by decapitation, and blood samples and epididymal adipose tissue were collected for hormonal determination and gene expression evaluation (IL-6, monocyte chemoattractant protein-1 (MCP-1), TNF-alpha, leptin and resistin). There was no detectable lycopene in the plasma of the C and DIO groups. However, the mean lycopene plasma concentration was 24 nmol in the DIO + L group. Although lycopene supplementation did not affect BW or adiposity, it significantly decreased leptin, resistin and IL-6 gene expression in epididymal adipose tissue and plasma concentrations. Also, it significantly reduced the gene expression of MCP-1 in epididymal adipose tissue. Lycopene affects adipokines by reducing leptin, resistin and plasma IL-6 levels. These data suggest that lycopene may be an effective strategy in reducing inflammation in obesity. (AU)

FAPESP's process: 11/22786-0 - Influence of lycopene on oxidative stress markers in adipose tissue of obese rats
Grantee:Renata de Azevedo Melo Luvizotto Nascimento
Support Opportunities: Scholarships abroad - Research Internship - Post-doctor
FAPESP's process: 10/19746-4 - Effect of lycopene supplementation in experimental model of diet-induced obesity
Grantee:Renata de Azevedo Melo Luvizotto Nascimento
Support Opportunities: Scholarships in Brazil - Post-Doctoral
FAPESP's process: 11/19847-8 - Effect of lycopene on oxidative stress, inflammatory process and insulin resistance in adipose tissue of animals with nutritional overload
Grantee:Érika Imaizumi
Support Opportunities: Scholarships in Brazil - Scientific Initiation
FAPESP's process: 10/06100-9 - Effect of lycopene supplementation on obesity in experimental model Zucker rats
Grantee:Ana Lucia do Anjos Ferreira
Support Opportunities: Regular Research Grants