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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

The association between TNF-alpha and erectile dysfunction complaints

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Autor(es):
Matos, G. [1] ; Hirotsu, C. [1] ; Alvarenga, T. A. [1] ; Cintra, F. [1] ; Bittencourt, L. [1] ; Tufik, S. [1] ; Andersen, M. L. [1]
Número total de Autores: 7
Afiliação do(s) autor(es):
[1] Univ Fed Sao Paulo, Dept Psicobiol, Sao Paulo - Brazil
Número total de Afiliações: 1
Tipo de documento: Artigo Científico
Fonte: ANDROLOGY; v. 1, n. 6, p. 872-878, NOV 2013.
Citações Web of Science: 13
Resumo

Inflammatory markers like tumour necrosis factor-alpha (TNF-) have been related to erectile dysfunction (ED) and may interact with other cardiovascular risk factors such as obstructive sleep apnoea syndrome (OSAS). The aim of this study was to examine the inflammatory, metabolic and hormonal profile of men with or without ED complaints and/or OSAS recruited through the Epidemiologic Sleep Study (EPISONO). A sample of 363 men completed sexual questionnaires for ED and had physical and blood examinations. OSAS was evaluated by polysomnography and clinical assessment. The blood samples were used for determination of TNF-, interleukin-6, leptin, cholesterol and fractions, triglycerides, homocysteine, glucose and hormonal levels. After controlling for confounding factors, men with ED complaints presented higher systolic blood pressure and TNF-, independent of OSAS. Significant interaction between ED and OSAS was only observed for neck circumference, which was higher in ED men with OSAS than men with OSAS without ED and men with ED without OSAS. Binary logistic regression showed that the predictor factors for ED were age >43years, myocardial infarction events, TNF- and systolic blood pressure. Finally, a receiver-operating characteristics curve suggested a cut-off point of 9.95pg/mL for TNF- with sensitivity of 60% and specificity of 59% in men with ED complaints. Furthermore, there was a significant association between high levels of TNF- (>9.95pg/mL) and the presence of ED complaints. The results showed that there was an association between TNF- levels and ED complaints in men independent of OSAS. (AU)

Processo FAPESP: 10/50129-1 - Insuficiência renal crônica, restrição de sono e sildenafil: consequências renais, cardíacas e sexuais em um modelo animal
Beneficiário:Camila Hirotsu
Linha de fomento: Bolsas no Brasil - Doutorado Direto
Processo FAPESP: 10/15110-8 - Sono e morte súbita nas epilepsias: provável base molecular?
Beneficiário:Gabriela de Matos Barbosa Pimenta
Linha de fomento: Bolsas no Brasil - Pós-Doutorado
Processo FAPESP: 11/12325-6 - Efeitos da privação de sono e da síndrome da apnéia obstrutiva do sono na função reprodutiva em homens
Beneficiário:Tathiana Aparecida Fernandes de Alvarenga
Linha de fomento: Bolsas no Brasil - Pós-Doutorado