| Texto completo | |
| Autor(es): |
Belai, Eduardo Bertoli
[1]
;
de Oliveira, Carine Ervolino
[2]
;
Gasparoto, Thas Helena
[1]
;
Ramos, Rodrigo Nalio
[1]
;
Torres, Sergio Aparecido
[1]
;
Garlet, Gustavo Pompermaier
[1]
;
Cavassani, Karen Angelica
[3]
;
Silva, Joao Santana
[4]
;
Campanelli, Ana Paula
[1]
Número total de Autores: 9
|
| Afiliação do(s) autor(es): | [1] Univ Sao Paulo, Bauru Sch Dent, Dept Biol Sci, BR-17012901 Sao Paulo - Brazil
[2] Univ Sao Paulo, Bauru Sch Dent, Dept Stomatol, BR-17012901 Sao Paulo - Brazil
[3] Univ Michigan, Sch Med, Dept Pathol, Ann Arbor, MI 48109 - USA
[4] Univ Sao Paulo, Sch Med Ribeirao Preto, Dept Biochem & Immunol, BR-14049900 Sao Paulo - Brazil
Número total de Afiliações: 4
|
| Tipo de documento: | Artigo Científico |
| Fonte: | Carcinogenesis; v. 35, n. 2, p. 424-431, FEB 2014. |
| Citações Web of Science: | 18 |
| Resumo | |
Engagement of programmed death-1 (PD-1) with its two ligands {[}programmed death ligand-1 (PD-L1) and PD-L2] has been associated with the suppression of tumor-reactive T cells; however, the underlying mechanism for this T-cell dysfunction is not clear. We hypothesized that PD-1 and PD-L1 signals are, in part, responsible for squamous cell carcinoma (SCC) escape from immune antitumor regulation by modulation of the tumor environment. In the present study, we used a multistage model of SCC to examine the role of PD-1/PD-L1 activation during tumor development. Tumor sites presented an increased percentage of CD4 and CD8 T cells expressing PD-1 when compared with non-tumorigenic control mice, whereas the expression of PD-L1 was particularly increased in F4/80 macrophages in tumor sites. Further, the systemic immune neutralization of PD-1 resulted in a decreased number and delayed incidence rate of papillomas followed by a differential expression of cytokeratins, suggesting that the PD-1PD-L1 interaction contributes to the progression of SCC by downregulation of antitumor responses. In fact, blocking PD-1 increased the percentage of CD8 and CD4 T cells, and the levels of interferon- in the tumor sites. Our results indicated involvement of PD-1 T cells in SCC development and in the modulation of the inflammatory immune response. (AU) | |
| Processo FAPESP: | 08/10999-7 - Modulação da resposta imune durante o desenvolviemnto de carcinoma espinocelular |
| Beneficiário: | Ana Paula Campanelli |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |
| Processo FAPESP: | 09/14127-7 - O papel do inflamassoma nos tumores quimicamente induzidos |
| Beneficiário: | Thaís Helena Gasparoto |
| Modalidade de apoio: | Bolsas no Brasil - Pós-Doutorado |
| Processo FAPESP: | 09/03471-9 - Modulação da resposta imune durante o desenvolvimento de carcinoma espinocelular |
| Beneficiário: | Eduardo Bertoli Belai |
| Modalidade de apoio: | Bolsas no Brasil - Mestrado |
| Processo FAPESP: | 06/01617-8 - Estudo do papel de células T regulatórias no desenvolvimento de carcinoma oral de células escamosas |
| Beneficiário: | Rodrigo Nalio Ramos |
| Modalidade de apoio: | Bolsas no Brasil - Iniciação Científica |