| Texto completo | |
| Autor(es): |
De Morais Nunes, Edsel Renata
[1]
;
Zukurov, Jean Paulo
[1]
;
Maricato, Juliana Terzi
[2]
;
Araripe Sucupira, Maria Cecilia
[1]
;
Diaz, Ricardo Sobhie
[1]
;
Ramos Janini, Luiz Mario
[1, 2]
Número total de Autores: 6
|
| Afiliação do(s) autor(es): | [1] Univ Fed Sao Paulo, Dept Med, Sao Paulo - Brazil
[2] Univ Fed Sao Paulo, Dept Microbiol Immunol & Parasitol, Sao Paulo - Brazil
Número total de Afiliações: 2
|
| Tipo de documento: | Artigo Científico |
| Fonte: | PLoS One; v. 9, n. 1 JAN 3 2014. |
| Citações Web of Science: | 1 |
| Resumo | |
The present study investigated the prevalence of HIV-1 multiple infections in a population composed by 47 patients under HAART failure and enrolled at the National DST/AIDS, Program, Ministry of Health, Brazil. Detection of multiple infections was done using a previously published RFLP assay for the HIV-1 protease gene, which is able of distinguishing between infections caused by a single or multiple HIV-1 subtypes. Samples with multiple infections were cloned, and sequence data submitted to phylogenetic analysis. We were able to identify 17 HIV-1 multiple infections out of 47 samples. Multiple infections were mostly composed by a mixture of recombinant viruses (94%), with only one case in which protease gene pure subtypes B and F were recovered. This is the first study that reports the prevalence of multiple infections and intersubtype recombinants in a population undergoing HAART in Brazil. Based on the data there was a steep increase of multiple infections after the introduction of the combined antiretroviral therapy in Brazil. Cases of multiple infections may be associated with HIV-1 genetic diversity through recombination allowing for the generation of viruses showing a combination of resistance mutations. (AU) | |
| Processo FAPESP: | 09/11216-9 - Estudo da Prevalência das Infecções Duplas do HIV-1 em indivíduos em falha virológica submetidos ao Tratamento Antiretroviral Intensivo. |
| Beneficiário: | Edsel Renata de Morais Nunes |
| Modalidade de apoio: | Bolsas no Brasil - Mestrado |
| Processo FAPESP: | 09/10915-0 - Estudo da prevalência das infecções duplas do HIV-1 em indivíduos em falha virológica submetidos ao tratamento antiretroviral intensivo |
| Beneficiário: | Luiz Mário Ramos Janini |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |