The thickness of posterior cortical areas is related to executive dysfunction in Alzheimer's disease

Autor(es)

Vasconcelos, Luciano de Gois ^[1] ; Jackowski, Andrea Parolin ^[2] ; de Oliveira, Maira Okada ^[3] ; Ribeiro Flor, Yona Mayara ^[2] ; Lino Souza, Altay Alves ^[1] ; Amodeo Bueno, Orlando Francisco ^[1] ; Dozzi Brucki, Sonia Maria ^[3]

Afiliação do(s) autor(es)

^[1] Univ Fed Sao Paulo, Dept Psychobiol, Sao Paulo - Brazil

^[2] Univ Fed Sao Paulo, Dept Psychiat, LiNC, Sao Paulo - Brazil

^[3] Univ Sao Paulo, Fac Med, Hosp Clin, Cognit Neurol & Behav Grp, Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Clinics; v. 69, n. 1, p. 28-37, 2014.
• Citações Web of Science: 8

Resumo

OBJECTIVE: To establish whether alterations of brain structures in Alzheimer's disease are associated with executive dysfunction. METHODS: Nineteen patients with Alzheimer's disease and 22 older control subjects underwent a comprehensive evaluation. The clock drawing test, digit span test, executive motor function test, Behavioral Assessment of the Dysexecutive Syndrome battery (Rule Shift Cards test), and Stroop test were used to evaluate executive dysfunction. A multiparametric approach using the FreeSurfer image analysis suite provided a description of volumetric and geometric features of the gray matter structures. RESULTS: The cortical thickness maps showed a negative correlation between the Behavioral Assessment of the Dysexecutive Syndrome battery (Rule Shift Cards test) and the right middle frontal gyrus; a positive correlation between the executive motor function test and the left superior parietal gyrus, left middle temporal gyrus, bilateral supramarginal gyri, right middle frontal gyrus, and right precuneus; a negative correlation between the Stroop test (part III) and the right superior parietal gyrus; and a negative correlation between the Stroop test (part III) and the right middle temporal gyrus. CONCLUSION: Executive dysfunction in Alzheimer's disease is correlated with alterations not only in the frontal areas but also within many temporal and parietal regions. (AU)

• Processo FAPESP: 08/11282-9 - Disfunção executiva em pacientes com Doença de Alzheimer leve e indivíduos cognitivamente normais: correlação com volumetria e medidas de integridade neuronal por imagem dos tensores de difusão de estruturas encefálicas
• Beneficiário: Orlando Francisco Amodeo Bueno
• Modalidade de apoio: Auxílio à Pesquisa - Regular