Adhesion Molecules in Primary Oral Mucosal Melanoma: Study of Claudins, Integrins and Immunoglobulins in a Series of 35 Cases

Autor(es)

Bologna, Sheyla Batista ^{[1, 2]} ; Nico, Marcello Menta S. ^{[1, 2]} ; Hsieh, Ricardo ^{[1, 2]} ; Coutinho-Camillo, Claudia Malheiros ^[3] ; Buim, Marcilei E. ^[3] ; Fernandes, Juliana Dumet ^[4] ; Sangueza, Martin ^[5] ; Soares, Fernando Augusto ^{[6, 3]} ; Lourenco, Silvia Vanessa ^{[6, 1, 2]}

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Dept Dermatol, Sch Med, BR-05508000 Sao Paulo - Brazil

^[2] Univ Sao Paulo, Immunopathol Lab, Inst Trop Med, BR-05508000 Sao Paulo - Brazil

^[3] Hosp AC Camargo Fund Antonio Prudente, Dept Pathol, Sao Paulo - Brazil

^[4] Univ Fed Bahia, Sch Med, Dept Dermatol, Salvador, BA - Brazil

^[5] Hosp Obrero, Dept Pathol, La Paz - Bolivia

^[6] Univ Sao Paulo, Sch Dent, Dept Pathol, BR-05508000 Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: AMERICAN JOURNAL OF DERMATOPATHOLOGY; v. 35, n. 5, p. 541-554, JUL 2013.
• Citações Web of Science: 6

Resumo

Primary oral mucosal melanoma is a rare aggressive tumor. Recent studies have demonstrated a correlation between increased tumor invasion and the metastatic phenotype and altered adhesion molecule expression profiles. The present study analyzed the expression of integrins, claudins, and immunoglobulin-like adhesion molecules in oral mucosal melanomas and correlated results with clinical parameters. Immunohistochemical analyses of the expression patterns of these molecules were performed on thirty-five cases of primary oral mucosal melanomas organized in a tissue microarray. The results were correlated with clinical and histological features of the cohort. A number of integrin subunits were negative and this was related with vascular invasion. Positivity of integrin beta-3 and CD166 (activated leukocyte cell adhesion molecule) was statistically associated with extensive vascular invasion (P < 0.05). Lower expression of CD54 (intercellular cell adhesion molecule) was associated with cases with extensive necrosis. Most cases with metastatic disease were negative for CD66 (carcinoembryonic antigen-related cell adhesion molecule). Several subunits of claudins were negative and, although not statistically significant, this lack of expression was partially associated with histological factors of poor prognosis. Altered patterns of adhesion molecule expression, mainly integrins and immunoglobulin-like proteins, may participate in the pathogenesis and outcome of oral mucosal melanomas. (AU)

• Processo FAPESP: 06/56625-5 - Melanomas orais: estudo morfologico e analise imuno-histoquimica de marcadores tumorais e moleculas de adesao por meio de "tissue microarray".
• Beneficiário: Silvia Vanessa Lourenço
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 07/50319-2 - Melanomas orais: estudo morfológico e análise imuno-histoquímica das claudinas e sua relação com marcadores tumorais: análise por meio de tissue microarray
• Beneficiário: Sheyla Batista Bologna Lopes
• Modalidade de apoio: Bolsas no Brasil - Iniciação Científica