| Texto completo | |
| Autor(es): |
Millington, Rebecca S.
[1, 2]
;
Yasuda, Clarissa L.
[3]
;
Jindahra, Panitha
[4]
;
Jenkinson, Mark
[1, 2]
;
Barbur, John L.
[5]
;
Kennard, Christopher
[2]
;
Cendes, Fernando
[3]
;
Plant, Gordon T.
[6, 7]
;
Bridge, Holly
[1, 2]
Número total de Autores: 9
|
| Afiliação do(s) autor(es): | [1] Univ Oxford, Oxford Ctr Funct Magnet Resonance Imaging Brain F, Oxford OX3 9DU - England
[2] Univ Oxford, Nuffield Dept Clin Neurosci, Oxford OX3 9DU - England
[3] Univ Estadual Campinas, Dept Neurol, UNICAMP, Sao Paulo - Brazil
[4] Ramathibodi Hosp, Dept Med, Div Neurol, Bangkok - Thailand
[5] City Univ London, Appl Vis Res Ctr, London EC1V 0HB - England
[6] Natl Hosp Neurol & Neurosurg, London WC1N 3BG - England
[7] Moorfields Eye Hosp, London - England
Número total de Afiliações: 7
|
| Tipo de documento: | Artigo Científico |
| Fonte: | JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY; v. 85, n. 4, p. 379-386, APR 2014. |
| Citações Web of Science: | 10 |
| Resumo | |
Background The existence of transsynaptic retrograde degeneration (TRD) in the human visual system has been established, however the dependence of TRD on different factors such as lesion location, size and manner of lesion acquisition has yet to be quantified. Methods We obtained T1-weighted structural and diffusion-weighted images for 26 patients with adult-acquired or congenital hemianopia and 12 age-matched controls. The optic tract (OT) was defined and measured in the structural and diffusion-weighted images, and degeneration assessed by comparing the integrity of tracts in the lesioned and in the undamaged hemisphere. Results OT degeneration was found in all patients with established lesions, regardless of lesion location. In patients with acquired lesions, the larger the initial lesion, the greater is the resulting TRD. However, this was not the case for congenital patients, who generally showed greater degeneration than would be predicted by lesion size. A better predictor of TRD was the size of the visual field deficit, which was correlated with degeneration across all patients. Interestingly, although diffusion-weighted imaging (DWI) is more frequently used to examine white matter tracts, in this study the T1-weighted scans gave a better indication of the extent of tract degeneration. Conclusions We conclude that TRD of the OT occurs in acquired and congenital hemianopia, is correlated with visual field loss, and is most severe in congenital cases. Understanding the pattern of TRD may help to predict effects of any visual rehabilitation training. (AU) | |
| Processo FAPESP: | 09/51425-6 - Displasia cortical focal: investigacao pre-cirurgica multimodal e desenvolvimento de softwares para diagnostico e planejamento cirurgico |
| Beneficiário: | Clarissa Lin Yasuda |
| Modalidade de apoio: | Bolsas no Brasil - Pós-Doutorado |