Coacervate whey protein improves inflammatory milieu in mice fed with high-fat diet

Autor(es):Mostrar menos -

Moreno, Mayara Franzoi ^[1] ; de Morais Honorato de Souza, Gabriel Inacio ^[1] ; Losinskas Hachul, Ana Claudia ^[1] ; dos Santos, Bruno ^[1] ; Okuda, Marcos Hiromu ^[1] ; Pinto Neto, Nelson Inacio ^[1] ; Boldarine, Valter Tadeu ^[1] ; Esposito, Elisa ^[2] ; Ribeiro, Eliane Beraldi ^[1] ; da Penha Oller do Nascimento, Claudia Maria ^[1] ; Ganen, Aline de Piano ^[1] ; Oyama, Lila Missae ^[1]

Afiliação do(s) autor(es)

^[1] Univ Fed Sao Paulo, Dept Fisiol, Disciplina Fisiol Nutr, Sao Paulo - Brazil

^[2] Univ Fed Sao Paulo, Inst Ciencias & Tecnol, Sao Jose Dos Campos, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: NUTRITION & METABOLISM; v. 11, MAR 28 2014.
• Citações Web of Science: 3

Resumo

Background: Functional foods with bioactive properties may help in treat obesity, as they can lead to a decreased risks of inflammatory diseases. The aim of this study was to investigate the effects of chitosan coacervate whey protein on the proinflammatory processes in mice fed with high-fat diet. Methods: Mice were divided into two groups receiving either a normolipidic or high-fat diet; the animals in each of the two diet groups were given a diet supplement of either coacervate (gavage, 36 mg protein/kg of body weight) or tap water for four weeks {[}groups: normolipidic diet plus water (C); normolipidic diet and coacervate (CC); high-fat diet and water (H); and high-fat diet and coacervate (HC)]. Results: The high-fat diet promoted inflammation, possibly by decreased adiponectin/sum of adipose tissues ratio and increased phosphorylation of NF-kappa B p50. In HC we observed a positive correlation between IL-10 and TNF-alpha in mesenteric adipose tissue, retroperitoneal adipose tissue and liver tissue. We also observed a positive correlation between lipopolisaccharide with IL-10 in the liver tissue. Conclusions: High-fat diet treatment promoted metabolic alterations and inflammation, and chitosan coacervate whey protein modulated inflammatory milieu. (AU)

• Processo FAPESP: 11/04310-9 - Investigação de um novo alimento funcional, coacervado a base de proteínas do soro de leite e quitosana, sobre a resposta inflamatória em camundongos obesos induzido por dieta hiperlipídica
• Beneficiário: Mayara Franzoi Moreno
• Modalidade de apoio: Bolsas no Brasil - Mestrado