Polycaprolactone nanoparticles containing encapsulated progesterone prepared using a scCO(2) emulsion drying technique

Autor(es)

Guilherme, Marcos R. ^[1] ; Mauricio, Marcos R. ^[1] ; Tenorio-Neto, Ernandes T. ^[1] ; Kunita, Marcos H. ^[1] ; Cardozo-Filho, Lucio ^[2] ; Cellet, Thelma S. P. ^[1] ; Pereira, Guilherme M. ^[1] ; Muniz, Edvani C. ^[1] ; da Rocha, Sandro R. P. ^{[3, 4]} ; Rubira, Adley F. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Estadual Maringa, Dept Quim, BR-87020900 Maringa, Parana - Brazil

^[2] Univ Estadual Maringa, Dept Engn Quim, BR-87020900 Maringa, Parana - Brazil

^[3] Wayne State Univ, Coll Engn Chem Engn & Mat Sci, Detroit, MI 48082 - USA

^[4] Univ Tieradentes, Inst Tecnol & Pesquisa, Ctr NanoMed CNanoMed, BR-49032490 Aracaju, SE - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Materials Letters; v. 124, p. 197-200, JUN 1 2014.
• Citações Web of Science: 7

Resumo

Well-defined polycaprolactone (PCL) nanoparticles loaded with progesterone (P4) were obtained by scCO(2) antisolvent expansion of emulsions as a drying strategy. PCL nanoparticles with an average diameter of 82 nm were formed by the emulsification of an ethyl acetate-water mixture containing P4 and poly(vinyl alcohol) (PVA) as the stabilizing agent under ultrasonic irradiation. Emulsion particles were dried in scCO(2) and the results were compared with drying at ambient conditions. The scCO(2) expansion-dried PCL nanoparticles showed a smaller average diameter and the dynamic light scattering (DLS) analysis revealed a narrower particle size distribution when compared to the diameter of nanoparticles formed with the conventional process (174 nm). The use of scCO(2) expansion technology as a drying strategy for the production of PCL nanoparticles with a narrow size distribution for P4 delivery represents an improvement over the conventional drying processes. (C) 2014 Elsevier B.V. All rights reserved. (AU)

• Processo FAPESP: 06/60909-9 - Progesterona em nanopaticulas suportada em phb-v e pcl,para utilizacao em reproducao de femeas bovinas: uma alternativa de tecnologia limpa ("green technology").
• Beneficiário: Ed Hoffmann Madureira
• Modalidade de apoio: Auxílio à Pesquisa - Regular