Test-Retest Reliability of fMRI Activation Generated by Different Saccade Tasks

Autor(es)

Lukasova, Katerina ^{[1, 2]} ; Sommer, Jens ^[3] ; Nucci-da-Silva, Mariana P. ^[1] ; Vieira, Gilson ^{[1, 4]} ; Blanke, Marius ^[5] ; Bremmer, Frank ^[5] ; Sato, Joao R. ^[6] ; Kircher, Tilo ^[3] ; Amaro, Jr., Edson ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Fac Med, NIF LIM44, BR-05403001 Sao Paulo - Brazil

^[2] Univ Cruzeiro Sul, Fac Psychol, Sao Paulo - Brazil

^[3] Univ Marburg, Dept Psychiat, Marburg - Germany

^[4] Univ Sao Paulo, Bioinformat Grad Program, BR-05403001 Sao Paulo - Brazil

^[5] Univ Marburg, Dept Neurophys, Marburg - Germany

^[6] Univ Fed ABC, Ctr Math Computat & Cognit, Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Journal of Magnetic Resonance Imaging; v. 40, n. 1, p. 37-46, JUL 2014.
• Citações Web of Science: 4

Resumo

Purpose: To assess the reproducibility of brain-activation and eye-movement patterns in a saccade paradigm when comparing subjects, tasks, and magnetic resonance (MR) systems. Materials and Methods: Forty-five healthy adults at two different sites (n = 45) performed saccade tasks with varying levels of target predictability: predictable (PRED), position predictable (pPRED), time predictable (tPRED), and prosaccade (SAC). Eye-movement pattern was tested with a repeated-measures analysis of variance. Activation maps reproducibility were estimated with the cluster overlap Jaccard index and signal variance coefficient of determination for within-subjects test-retest data, and for between-subjects data from the same and different sites. Results: In all groups latencies increased with decreasing target predictability: PRED < pPRED < tPRED < SAC (P < 0,001). Activation overlap was good to fair (>0.40) in all tasks in the within-subjects test-retest comparisons and poor (<0.40) in the tPRED for different subjects. The overlap of the different tasks for within-groups data was higher (0.40-0.68) than for the between-groups data (0.30-0.50). Activation consistency was 60-85% in the same subjects, 50-79% in different subjects, and 50-80% in different sites. In SAC, the activation found in the same and in different subjects was more consistent than in other tasks (50-80%). Conclusion: The predictive saccade tasks produced evidence for brain-activation and eye-movement reproducibility. (AU)

• Processo FAPESP: 05/56464-9 - Centro de Imagem em Neurociências da Faculdade de Medicina da Universidade de São Paulo
• Beneficiário: Giovanni Guido Cerri
• Modalidade de apoio: Auxílio à Pesquisa - Programa CINAPCE - Temático