Blood flow and oxygenation changes due to low-frequency repetitive transcranial magnetic stimulation of the cerebral cortex

Autor(es):Mostrar menos -

Mesquita, Rickson C. ^[1] ; Faseyitan, Olufunsho K. ^[2] ; Turkeltaub, Peter E. ^[3] ; Buckley, Erin M. ^[4] ; Thomas, Amy ^[5] ; Kim, Meeri N. ^[6] ; Durduran, Turgut ^[7] ; Greenberg, Joel H. ^[8] ; Detre, John A. ^[9] ; Yodh, Arjun G. ^[10] ; Hamilton, Roy H. ^[11]

Afiliação do(s) autor(es):Mostrar menos -

^[1] Univ Penn. Dept Phys & Astron

^[2] Univ Penn. Dept Neurol

^[3] Georgetown Univ. Med Ctr

^[4] Univ Penn. Dept Phys & Astron

^[5] Univ Penn. Dept Neurol

^[6] Univ Penn. Dept Phys & Astron

^[7] Mediterranean Technol Pk. Inst Ciencies Foton

^[8] Univ Penn. Dept Neurol

^[9] Univ Penn. Dept Neurol

^[10] Univ Penn. Dept Phys & Astron

^[11] Univ Penn. Dept Neurol

• Tipo de documento: Artigo Científico
• Fonte: Journal of Biomedical Optics; v. 18, n. 6 JUN 2013.
• Citações Web of Science: 15

Resumo

Transcranial magnetic stimulation (TMS) modulates processing in the human brain and is therefore of interest as a treatment modality for neurologic conditions. During TMS administration, an electric current passing through a coil on the scalp creates a rapidly varying magnetic field that induces currents in the cerebral cortex. The effects of low-frequency (1 Hz), repetitive TMS (rTMS) on motor cortex cerebral blood flow (CBF) and tissue oxygenation in seven healthy adults, during/after 20 min stimulation, is reported. Noninvasive optical methods are employed: diffuse correlation spectroscopy (DCS) for blood flow and diffuse optical spectroscopy (DOS) for hemoglobin concentrations. A significant increase in median CBF (33%) on the side ipsilateral to stimulation was observed during rTMS and persisted after discontinuation. The measured hemodynamic parameter variations enabled computation of relative changes in cerebral metabolic rate of oxygen consumption during rTMS, which increased significantly (28%) in the stimulated hemisphere. By contrast, hemodynamic changes from baseline were not observed contralateral to rTMS administration (all parameters, p > 0.29). In total, these findings provide new information about hemodynamic/metabolic responses to low-frequency rTMS and, importantly, demonstrate the feasibility of DCS/DOS for noninvasive monitoring of TMS-induced physiologic effects. (C) 2013 Society of Photo-Optical Instrumentation Engineers (SPIE) (AU)

• Processo FAPESP: 12/02500-8 - Desenvolvimento de instrumentação e metodologias para monitoramento de oxigenação, fluxo sanguíneo e metabolismo cerebral com espectroscopias ópticas de difusão
• Beneficiário: Rickson Coelho Mesquita
• Modalidade de apoio: Auxílio à Pesquisa - Jovens Pesquisadores