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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Blood flow and oxygenation changes due to low-frequency repetitive transcranial magnetic stimulation of the cerebral cortex

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Author(s):
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Mesquita, Rickson C. [1] ; Faseyitan, Olufunsho K. [2] ; Turkeltaub, Peter E. [3] ; Buckley, Erin M. [4] ; Thomas, Amy [5] ; Kim, Meeri N. [6] ; Durduran, Turgut [7] ; Greenberg, Joel H. [8] ; Detre, John A. [9] ; Yodh, Arjun G. [10] ; Hamilton, Roy H. [11]
Total Authors: 11
Affiliation:
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[1] Univ Penn. Dept Phys & Astron
[2] Univ Penn. Dept Neurol
[3] Georgetown Univ. Med Ctr
[4] Univ Penn. Dept Phys & Astron
[5] Univ Penn. Dept Neurol
[6] Univ Penn. Dept Phys & Astron
[7] Mediterranean Technol Pk. Inst Ciencies Foton
[8] Univ Penn. Dept Neurol
[9] Univ Penn. Dept Neurol
[10] Univ Penn. Dept Phys & Astron
[11] Univ Penn. Dept Neurol
Total Affiliations: 11
Document type: Journal article
Source: Journal of Biomedical Optics; v. 18, n. 6 JUN 2013.
Web of Science Citations: 15
Abstract

Transcranial magnetic stimulation (TMS) modulates processing in the human brain and is therefore of interest as a treatment modality for neurologic conditions. During TMS administration, an electric current passing through a coil on the scalp creates a rapidly varying magnetic field that induces currents in the cerebral cortex. The effects of low-frequency (1 Hz), repetitive TMS (rTMS) on motor cortex cerebral blood flow (CBF) and tissue oxygenation in seven healthy adults, during/after 20 min stimulation, is reported. Noninvasive optical methods are employed: diffuse correlation spectroscopy (DCS) for blood flow and diffuse optical spectroscopy (DOS) for hemoglobin concentrations. A significant increase in median CBF (33%) on the side ipsilateral to stimulation was observed during rTMS and persisted after discontinuation. The measured hemodynamic parameter variations enabled computation of relative changes in cerebral metabolic rate of oxygen consumption during rTMS, which increased significantly (28%) in the stimulated hemisphere. By contrast, hemodynamic changes from baseline were not observed contralateral to rTMS administration (all parameters, p > 0.29). In total, these findings provide new information about hemodynamic/metabolic responses to low-frequency rTMS and, importantly, demonstrate the feasibility of DCS/DOS for noninvasive monitoring of TMS-induced physiologic effects. (C) 2013 Society of Photo-Optical Instrumentation Engineers (SPIE) (AU)

FAPESP's process: 12/02500-8 - Instrumentation and methodology development for cerebral oxygenation, blood flow and metabolic monitoring with diffuse optical spectroscopies
Grantee:Rickson Coelho Mesquita
Support Opportunities: Research Grants - Young Investigators Grants