| Texto completo | |
| Autor(es): |
Yasuda, Clarissa L.
[1, 2]
;
Guimaraes, Catarina A.
[1, 2]
;
Guerreiro, Marilisa M.
[1]
;
Boscariol, Mirela
[1]
;
Oliveira, Ecila P. M.
[1]
;
Teixeira, Karine C.
[1]
;
Costa, Andre L. F.
[1, 2]
;
Beltramini, Guilherme C.
[3, 2]
;
Cendes, Fernando
[1, 2]
Número total de Autores: 9
|
| Afiliação do(s) autor(es): | [1] Univ Estadual Campinas, UNICAMP, Dept Neurol, Campinas, SP - Brazil
[2] Univ Estadual Campinas, UNICAMP, Lab Neuroimaging, Campinas, SP - Brazil
[3] Univ Estadual Campinas, Inst Phys Gleb Wataghin, Campinas, SP - Brazil
Número total de Afiliações: 3
|
| Tipo de documento: | Artigo Científico |
| Fonte: | JOURNAL OF NEUROLOGY; v. 261, n. 7, p. 1374-1380, JUL 2014. |
| Citações Web of Science: | 2 |
| Resumo | |
Congenital bilateral perisylvian syndrome (CBPS) presents with heterogeneous clinical manifestations such as pseudobulbar palsy, language disorder, variable cognitive deficits, epilepsy, and perisylvian abnormalities (most frequently polymicrogyria) on imaging studies. We investigated the relationship between seizures and extent of gray matter (GM) and white matter (WM) abnormalities using voxel-based morphometry (VBM) of brain magnetic resonance imaging (MRI) as well the association between seizures, structural abnormalities and cognitive ability. In this cross-sectional study, we evaluated 51 healthy volunteers and 18 patients with CBPS with epilepsy (seizure group, n = 7) and without (non-seizure group, n = 11). We used VBM (SPM8/DARTEL) to investigate areas with excess and atrophy of both gray and white matter, comparing groups of patients with controls. Intellectual ability of patients was assessed by the WISC-III or WAIS-III. Both groups with CBPS and the control group were homogeneous with respect to gender (p = 0.07) and age (p = 0.065). Besides perisylvian polymicrogyria, the seizure group exhibited areas with GM and WM reduction including temporal, frontal, parietal and occipital lobes. In contrast, we identified fewer areas with GM and WM reduction in the non-seizure group. The seizure group presented worse intellectual performance (performance IQ and global IQ) than the non-seizure group. The seizure group presented with a more widespread pattern of cortical and sub-cortical abnormalities, as well as worse cognition. Our results suggest that patients with CBPS and epilepsy appear to have widespread neuronal damage that goes beyond the areas with MRI-visible perisylvian polymicrogyria. (AU) | |
| Processo FAPESP: | 05/59258-0 - Comparacao prospectiva entre os tratamentos clinico e cirurgico para epilepsia de lobo temporal medial. |
| Beneficiário: | Clarissa Lin Yasuda |
| Modalidade de apoio: | Bolsas no Brasil - Doutorado |
| Processo FAPESP: | 06/56257-6 - Síndrome perisylviana: avaliação neuropsicológica e ressonância magnética funcional |
| Beneficiário: | Catarina Abraão Guimarães |
| Modalidade de apoio: | Bolsas no Brasil - Pós-Doutorado |
| Processo FAPESP: | 07/00806-4 - Caracterização dos achados da avaliação do processamento auditivo em sujeitos com Síndrome Perisylviana |
| Beneficiário: | Mirela Boscariol |
| Modalidade de apoio: | Bolsas no Brasil - Mestrado |
| Processo FAPESP: | 07/59342-7 - Caracterizacao das manifestacoes neuropsicolinguisticas em criancas com epilepsia rolandica. |
| Beneficiário: | Ecila Paula dos Mesquita de Oliveira |
| Modalidade de apoio: | Bolsas no Brasil - Doutorado |