Genetic Association Study of Angiotensin II Receptor Types 1 (A168G) and 2 (T1247G and A5235G) Polymorphisms in Breast Carcinoma among Brazilian Women

Autor(es)

Garcia Molina Wolgien, Maria del Carmen ^[1] ; Cotrim Guerreiro da Silva, Ismael Dale ^[1] ; Pinto Nazario, Afonso Celso ^[1] ; Nakaie, Clovis Riuche ^[2] ; Alves Correa-Noronha, Silvana Aparecida ^[3] ; Ribeiro de Noronha, Samuel Marcos ^[3] ; Facina, Gil ^[1]

Afiliação do(s) autor(es)

^[1] Univ Fed Sao Paulo EPM UNIFESP, Escola Paulista Med, Dept Gynecol, Sao Paulo - Brazil

^[2] Univ Fed Sao Paulo EPM UNIFESP, Escola Paulista Med, Dept Biophys, Sao Paulo - Brazil

^[3] Univ Fed Sao Paulo EPM UNIFESP, Escola Paulista Med, Dept Surg, Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: BREAST CARE; v. 9, n. 3, p. 176-181, 2014.
• Citações Web of Science: 5

Resumo

Background: Many types of cancer are associated with polymorphisms of the renin-angiotensin system. Our aim was to assess possible association between single-nucleotide polymorphisms (SNPs) of the angiotensin II receptor types 1 (A168G), and 2 (T1247G and A5235G) with breast cancer. Patients and Methods: 242 participating subjects were genotyped and allocated to case or control groups. Results: Genotype distribution (in %) was: for AGTR1 (A168G): AA, AG, GG = 61, 30, 09 for cases, and 69, 25, 06 for controls (p = 0.55); for AGTR2 (T1247G): TT, TG, GG = 84, 12, 04 for cases, and 81, 17, 02 for controls (p = 0.45); for AGTR2 (A5235G): AA, AG, GG = 32, 67, 01 for cases, and 53, 28, 19 for controls (p < 0.0001). Women carrying genotypes AA/AG in the intronic region of angiotensin II type 2 receptor had an 11-fold higher risk of breast cancer than GG carriers. Conclusions: Many types of cancer have been associated with polymorphisms of the renin-angiotensin system. For SNP A5235G, the GG genotype seems to be protective against breast cancer. The other 2 SNPs showed no association. However, SNPs T1247G and A5235G were associated with at least 1 clinical variable, with G being a predictor of better outcome. The use of SNPs A5235G and T1247G (the latter to a lesser degree) as genetic markers should be considered. (AU)

• Processo FAPESP: 07/56480-0 - Síntese e estudos de peptídeos e análogos envolvidos principalmente no sistema renina-angiotensina e calicreína-cinina
• Beneficiário: Clovis Ryuichi Nakaie
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 08/50776-7 - Avaliacao genetica e estrutural de componentes do sistema renina angiotensina e sua eventual associacao ao cancer de mama.
• Beneficiário: Samuel Marcos Ribeiro de Noronha
• Modalidade de apoio: Bolsas no Brasil - Doutorado
• Processo FAPESP: 08/54383-0 - Avaliação bioquímica e genética da angiotensina-(1-7) e da enzima conversora de angiotensina 2 e sua eventual associação ao câncer de mama
• Beneficiário: Silvana Aparecida Alves Corrêa
• Modalidade de apoio: Auxílio à Pesquisa - Jovens Pesquisadores