Transmission of intra-cellular genetic information: A system proposal

Autor(es)

Faria, L. C. B. ^[1] ; Rocha, A. S. L. ^[1] ; Palazzo, Jr., R. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Estadual Campinas, Dept Commun, BR-13083852 Campinas, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Journal of Theoretical Biology; v. 358, p. 208-231, OCT 7 2014.
• Citações Web of Science: 3

Resumo

One of the great challenges of the scientific community on theories of genetic information, genetic communication and genetic coding is to determine a mathematical structure related to DNA sequences. In this paper we propose a model of an intra-cellular transmission system of genetic information similar to a model of a power and bandwidth efficient digital communication system in order to identify a mathematical structure in DNA sequences where such sequences are biologically relevant. The model of a transmission system of genetic information is concerned with the identification, reproduction and mathematical classification of the nucleotide sequence of single stranded DNA by the genetic encoder. Hence, a genetic encoder is devised where labelings and cyclic codes are established. The establishment of the algebraic structure of the corresponding codes alphabets, mappings, labelings, primitive polynomials (p(x)) and code generator polynomials (g(x)) are quite important in characterizing error-correcting codes subclasses of G-linear codes. These latter codes are useful for the identification, reproduction and mathematical classification of DNA sequences. The characterization of this model may contribute to the development of a methodology that can be applied in mutational analysis and polymorphisms, production of new drugs and genetic improvement, among other things, resulting in the reduction of time and laboratory costs. (C) 2014 Elsevier Ltd. All rights reserved. (AU)

• Processo FAPESP: 08/04992-0 - Código matemático de geração e decodificação de sequências de DNA e proteínas: utilização na identificação de ligantes e receptores
• Beneficiário: Márcio de Castro Silva Filho
• Modalidade de apoio: Auxílio à Pesquisa - Programa de Apoio à Propriedade Intelectual (PAPI/Nuplitec)
• Processo FAPESP: 07/56052-8 - Teoria da informação e códigos
• Beneficiário: Sueli Irene Rodrigues Costa
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 05/54618-9 - Decifrando os mecanismos moleculares envolvidos na localização intracelular de proteínas em plantas
• Beneficiário: Márcio de Castro Silva Filho
• Modalidade de apoio: Auxílio à Pesquisa - Temático