UNDERSTANDING THE BENEFICIAL EFFECTS OF DOXYCYCLINE ON THE DYSTROPHIC PHENOTYPE OF THE mdx MOUSE

Autor(es)

Pereira, Juliano Alves ^[1] ; Matsumura, Cintia Yuri ^[1] ; Minatel, Elaine ^[1] ; Marques, Maria Julia ^[1] ; Neto, Humberto Santo ^[1]

Afiliação do(s) autor(es)

^[1] Univ Estadual Campinas UNICAMP, Dept Biol Estrutural & Func, Inst Biol, BR-13083865 Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: MUSCLE & NERVE; v. 50, n. 2, p. 283-286, AUG 2014.
• Citações Web of Science: 3

Resumo

Introduction: The purpose of this study was to better understand the beneficial effects of doxycycline on the dystrophic muscles of the mdx mouse. Methods: Doxycycline (DOX) was administered for 36 days, starting on postnatal day 0, via drinking water. Untreated mdx mice received plain water for the same period and served as a control group. Results: DOX decreased the levels of metalloproteinase-9 and tumor necrosis factor-alpha in the biceps brachii and diaphragm of the mdx mice. It also reduced the total amount of calcium in the muscles studied, concomitant with an increase in the levels of calsequestrin 1. Conclusions: The results show that DOX can affect factors that are important in dystrophic pathogenesis and highlight its potential as a readily accessible therapy in clinical trials for treatment of Duchenne muscular dystrophy. (AU)

• Processo FAPESP: 11/51697-6 - Mecanismos de acao do acido eicosapentanoico (epa) na protecao a mionecrose em fibras musculares distroficas
• Beneficiário: Maria Julia Marques
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 08/54775-5 - Mecanismos de protecao da distrofia muscular: estudo proteomico e terapia farmacologica
• Beneficiário: Cintia Yuri Matsumura
• Modalidade de apoio: Bolsas no Brasil - Doutorado
• Processo FAPESP: 08/58491-1 - Mecanismos de proteção da distrofia muscular: estudo proteômico e terapia farmacológica
• Beneficiário: Maria Julia Marques
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 04/15526-9 - Proteínas reguladoras do cálcio e proteção à mionecrose na distrofia muscular de Duchenne
• Beneficiário: Maria Julia Marques
• Modalidade de apoio: Auxílio à Pesquisa - Regular