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Novas estratégias instrumentais no desenvolvimento de métodos analíticos automatizados e miniaturizados para a determinação de compostos orgânicos mediante cromatografia líquida acoplada a espectrometria de massas

Processo: 19/22724-7
Modalidade de apoio:Bolsas no Brasil - Pós-Doutorado
Data de Início da vigência: 01 de fevereiro de 2020
Data de Término da vigência: 31 de janeiro de 2023
Área de conhecimento:Ciências Exatas e da Terra - Química - Química Analítica
Pesquisador responsável:Fernando Mauro Lanças
Beneficiário:Deyber Arley Vargas Medina
Instituição Sede: Instituto de Química de São Carlos (IQSC). Universidade de São Paulo (USP). São Carlos , SP, Brasil
Vinculado ao auxílio:17/02147-0 - Cromatografia líquida em uma gota e seu acoplamento com espectrometria de massas: estratégias instrumentais, desenvolvimento de materiais, automatização e aplicações analíticas, AP.TEM
Assunto(s):Compostos orgânicos   Métodos analíticos de preparação de amostras   Miniaturização   Cromatografia líquida acoplada à espectrometria de massas   Espectrometria de massas por ionização por electrospray
Palavra(s)-Chave do Pesquisador:automated analytical methods | chip-base nano columns for liquid chromatography | coupling nanoLC to EI-mass spectrometry | instrument development | Liquid chromatography-mass spectrometry | miniaturized liquid chromatography | Cromatografia

Resumo

A principal demanda da Química Analítica moderna é o desenvolvimento de métodos cada vez mais rápidos, simples e eficientes que mediante a adequada associação do preparo da amostras, a cromatografia e a espectrometria de massas permitam obter resultados confiáveis, em pouco tempo, e com o mínimo impacto ambiental. Assim, o presente projeto busca auxiliar o projeto temático principal no alcance dos seus objetivos, mediante o desenvolvimento de sistemas analíticos abrangentes e de alta produtividade. Três eixos transversais do projeto temático serão abordados na execução da presente proposta: (i) o desenvolvimento de métodos automatizados de preparo de amostra, que permitam a simplificação das análises com de alta produtividade; (ii) a introdução e fabricação de novas colunas cromatográficas miniaturizadas, em formato de chip, com sistema de programação de temperatura incorporado, capazes de separar pequenas moléculas com alta eficiência e velocidade; e (iii) o acoplamento dos sistemas anteriores com a detecção mediante espectrometria de massas com fontes de ionização por electrospray (ESI-MS) e assistida por elétrons (EI-MS), com foco no desenvolvimento de aplicações analíticas targeted e untargeted. (AU)

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Publicações científicas (33)
(Referências obtidas automaticamente do Web of Science e do SciELO, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores)
VARGAS MEDINA, DEYBER ARLEY; PEREIRA DOS SANTOS, NATALIA GABRIELLY; DA SILVA BURATO, JULIANA SOARES; BASOLLI BORSATTO, JOAO VICTOR; LANCAS, FERNANDO MAURO. An overview of open tubular liquid chromatography with a focus on the coupling with mass spectrometry for the analysis of small molecules. Journal of Chromatography A, v. 1641, . (19/26263-4, 19/22724-7, 14/07347-9, 17/02147-0, 14/03765-0, 15/15462-5)
OLIVEIRA, THAIS CAMAROTTO; LANCAS, FERNANDO MAURO. Determination of selected herbicides employed in sugarcane crops by disposable pipette tip (DPX) extraction followed by LC-MS/MS and GC-MS/MS. Journal of Liquid Chromatography & Related Technologies, v. 44, n. 17-20, p. 8-pg., . (17/02147-0, 14/07347-9, 19/22724-7, 15/15462-5)
VARGAS MEDINA, DEYBER ARLEY; SOARES MACIEL, EDVALDO VASCONCELOS; DE TOFFOLI, ANA LUCIA; LANCAS, FERNANDO MAURO. Miniaturization of liquid chromatography coupled to mass spectrometry. 2. Achievements on modern instrumentation for miniaturized liquid chromatography coupled to mass spectrometry. TRAC-TRENDS IN ANALYTICAL CHEMISTRY, v. 128, . (17/02147-0, 15/15462-5, 14/07347-9, 19/22724-7)
DOS SANTOS, NATALIA GABRIELLY; MEDINA, DEYBER ARLEY VARGAS; LANCAS, FERNANDO MAURO. Microextraction by packed sorbent of N-nitrosamines from Losartan tablets using a high-throughput robot platform followed by liquid chromatography-tandem mass spectrometry. JOURNAL OF SEPARATION SCIENCE, v. 46, n. 17, p. 13-pg., . (15/15462-5, 19/22724-7, 17/02147-0, 14/07347-9, 19/26263-4)
DOS SANTOS, NATALIA GABRIELLY PEREIRA; MACIEL, EDVALDO VASCONCELOS SOARES; MEDINA, DEYBER ARLEY VARGAS; LANCAS, FERNANDO MAURO. NanoLC-EI-MS: Perspectives in Biochemical Analysis. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v. 24, n. 14, p. 14-pg., . (19/22724-7, 17/21984-0, 17/02147-0, 17/21985-6, 19/26263-4)
BORSATTO, JOAO V. B.; MACIEL, EDVALDO V. S.; CIFUENTES, ALEJANDRO; LANCAS, FERNANDO M.. Online Extraction Followed by LC-MS/MS Analysis of Lipids in Natural Samples: A Proof-of-Concept Profiling Lecithin in Seeds. FOODS, v. 12, n. 2, p. 12-pg., . (17/02147-0, 19/22724-7)
SARTORE, DOUGLAS MORISUE; VARGAS MEDINA, DEYBER ARLEY; COSTA, JOSE LUIZ; LANCAS, FERNANDO MAURO; SANTOS-NETO, ALVARO JOSE. Automated microextraction by packed sorbent of cannabinoids from human urine using a lab-made device packed with molecularly imprinted polymer. Talanta, v. 219, . (17/02147-0, 19/22724-7, 10/19910-9)
VARGAS MEDINA, DEYBER ARLEY; SOARES MACIEL, EDVALDO VASCONCELOS; LANCAS, FERNANDO MAURO. Miniaturization of liquid chromatography coupled to mass spectrometry. 3. Achievements on chip-based LC-MS devices. TRAC-TRENDS IN ANALYTICAL CHEMISTRY, v. 131, . (19/22724-7, 14/03765-0, 15/15462-5, 17/02147-0, 14/07347-9)
BORSATTO, JOAO V. B.; LANCAS, FERNANDO M. M.. Recent Trends in Graphene-Based Sorbents for LC Analysis of Food and Environmental Water Samples. Molecules, v. 28, n. 13, p. 21-pg., . (17/02147-0, 19/22724-7)
AKAMINE, LIDIA AKEMI; MEDINA, DEYBER ARLEY VARGAS; LANCAS, FERNANDO MAURO. Magnetic solid-phase extraction of gingerols in ginger containing products. Talanta, v. 222, . (17/02147-0, 10/19910-9, 19/22724-7)
DA SILVA, LUIS FELIPE; VARGAS MEDINA, DEYBER ARLEY; LANCAS, FERNANDO MAURO. Automated needle-sleeve based online hyphenation of solid-phase microextraction and liquid chromatography. Talanta, v. 221, . (14/07347-9, 14/03765-0, 15/15462-5, 17/02147-0, 19/22724-7)
MEDINA, DEYBER ARLEY VARGAS; MACIEL, EDVALDO VASCONCELOS SOARES; DOS SANTOS, NATALIA GABRIELLY PEREIRA; LANCAS, FERNANDO MAURO. The overshadowed role of electron ionization-mass spectrometry in analytical biotechnology. CURRENT OPINION IN BIOTECHNOLOGY, v. 82, p. 9-pg., . (17/02147-0, 19/22724-7)
ANDRADE, FELIPE N.; SANTOS-NETO, ALVARO JOSE; MEDINA, DEYBER ARLEY V.; LANCAS, FERNANDO M.. A molecularly imprinted polymer for microextraction by packed sorbent of sulfonylureas herbicides from corn samples. Journal of Food Composition and Analysis, v. 121, p. 7-pg., . (15/15462-5, 11/09898-4, 19/22724-7, 17/02147-0, 14/07347-9, 13/17425-4)
MEDINA, DEYBER ARLEY VARGAS; SARTORE, DOUGLAS MORISUE; MACIEL, EDVALDO VASCONCELOS SOARES; SANTOS-NETO, ALVARO JOSE; LANCAS, FERNANDO MAURO. Microextraction columns for automated sample preparation. A review focusing on fully miniaturized column switching and bioanalytical applications. ADVANCES IN SAMPLE PREPARATION, v. 3, p. 12-pg., . (19/22724-7, 17/02147-0, 14/07347-9, 15/15462-5)
DOS SANTOS, NATALIA GABRIELLY PEREIRA; MEDINA, DEYBER ARLEY VARGAS; LANCAS, FERNANDO MAURO. Water as a green solvent for sustainable sample preparation: single drop microextraction of N-nitrosamines from losartan tablets. ANALYTICAL AND BIOANALYTICAL CHEMISTRY, v. N/A, p. 10-pg., . (19/22724-7, 17/02147-0, 15/15462-5)
SOARES MACIEL, EDVALDO VASCONCELOS; PEREIRA DOS SANTOS, NATALIA GABRIELLY; VARGAS MEDINA, DEYBER ARLEY; LANCAS, FERNANDO MAURO. Electron ionization mass spectrometry: Quo vadis?. ELECTROPHORESIS, v. 43, n. 15, p. 14-pg., . (19/26263-4, 19/22724-7, 17/02147-0, 14/03765-0, 15/15462-5, 14/07347-9)
MARINS, LINCON COUTINHO; MONTEIRO, ALESSANDRA MAFFEI; LEAL, VIVANE LOPES; MEDINA, DEYBER ARLEY VARGAS; CARDENAS, EDWIN MARTIN; LANCAS, FERNANDO MAURO. A Compact Instrument for Temperature-Programming-Assisted Capillary-Nanoliquid Chromatography. SEPARATIONS, v. 12, n. 1, p. 17-pg., . (19/22724-7, 19/26263-4, 15/15462-5, 14/07347-9, 17/02147-0)
JORDAN-SINISTERRA, MARCELA; VARGAS MEDINA, DEYBER ARLEY; LANCAS, FERNANDO MAURO. Microextraction by packed sorbent of polycyclic aromatic hydrocarbons in brewed coffee samples with a new zwitterionic ionic liquid-modified silica sorbent. Journal of Food Composition and Analysis, v. 114, p. 9-pg., . (14/07347-9, 19/22724-7, 17/02147-0, 15/15462-5)
MEDINA, DEYBER ARLEY VARGAS; MACIEL, EDVALDO VASCONCELOS SOARES; LANCAS, FERNANDO MAURO. Modern automated sample preparation for the determination of organic compounds: A review on robotic and on-flow systems. TRAC-TRENDS IN ANALYTICAL CHEMISTRY, v. 166, p. 21-pg., . (17/02147-0, 19/22724-7, 17/21984-0, 17/21985-6)
MEDINA, DEYBER ARLEY VARGAS; CARDOSO, ALESSANDRA TIMOTEO; BORSATTO, JOAO VICTOR BASOLLI; LANCAS, FERNANDO MAURO. Open tubular liquid chromatography: Recent advances and future trends. JOURNAL OF SEPARATION SCIENCE, v. N/A, p. 22-pg., . (17/02147-0, 19/22724-7)
BORSATTO, JOAO V. B.; MACIEL, EDVALDO V. S.; LANCAS, FERNANDO M.. Investigation of the applicability of silica-graphene hybrid materials as stationary phases for capillary liquid chromatography. Journal of Chromatography A, v. 1685, p. 8-pg., . (17/02147-0, 19/22724-7, 14/07347-9, 15/15462-5)
MEDINA, DEYBER ARLEY VARGAS; LOZADA-BLANCO, ASDRUBAL; RODRIGUEZ, JULIE PAULIN GARCIA; LANCAS, FERNANDO MAURO; NETO, ALVARO JOSE SANTOS. An open-source smart fraction collector for isocratic preparative liquid chromatography. HARDWAREX, v. 15, p. 16-pg., . (19/22724-7, 17/02147-0, 14/07347-9, 15/15462-5)
MEDINA, DEYBER ARLEY VARGAS; CARDOSO, ALESSANDRA TIMOTEO; MACIEL, EDVALDO VASCONCELOS SOARES; LANCAS, FERNANDO M.. Current materials for miniaturized sample preparation: Recent advances and future trends. TRAC-TRENDS IN ANALYTICAL CHEMISTRY, v. 165, p. 26-pg., . (17/02147-0, 19/22724-7, 17/21984-0, 17/21985-6)
BORSATTO, JOAO VICTOR BASOLLI; MACIEL, EDVALDO VASCONCELOS SOARES; CIFUENTES, ALEJANDRO; LANCAS, FERNANDO MAURO. Applicability and Limitations of a Capillary-LC Column-Switching System Using Hybrid Graphene-Based Stationary Phases. Molecules, v. 28, n. 13, p. 14-pg., . (17/02147-0, 19/22724-7)
SANTOS, NATALIA G. P.; MEDINA, DEYBER A. V.; LANCAS, FERNANDO M.. Development of Wall-Coated Open Tubular Columns and Their Application to Nano Liquid Chromatography Coupled to Tandem Mass Spectrometry. Molecules, v. 28, n. 13, p. 15-pg., . (15/15462-5, 19/22724-7, 17/02147-0, 14/07347-9, 19/26263-4)
BOCELLI, MARCIO DAVID; VARGAS MEDINA, DEYBER ARLEY; GARCIA RODRIGUEZ, JULIE PAULIN; LANCAS, FERNANDO MAURO; SANTOS-NETO, ALVARO JOSE. Determination of parabens in wastewater samples via robot-assisted dynamic single-drop microextraction and liquid chromatography-tandem mass spectrometry. ELECTROPHORESIS, v. 43, n. 15, p. 10-pg., . (17/02147-0, 19/22724-7, 14/07347-9, 15/15462-5)
MEDINA, DEYBER ARLEY VARGAS; BURATO, JULIANA SOARES DA SILVA; BORSATTO, JOAO VICTOR BASOLLI; LANCAS, FERNANDO MAURO. Porous layer open tubular nano liquid chromatography directly coupled to electron ionization mass spectrometry. Journal of Chromatography A, v. 1674, p. 9-pg., . (17/02147-0, 19/22724-7, 14/07347-9, 15/15462-5)
VARGAS MEDINA, DEYBER ARLEY; PEREIRA DOS SANTOS, NATALIA GABRIELLY; SOARES MACIEL, EDVALDO VASCONCELOS; LANCAS, FERNANDO MAURO. Current prospects on nano liquid chromatography coupled to electron ionization mass spectrometry (nanoLC-EI-MS). Journal of Liquid Chromatography & Related Technologies, v. 44, n. 17-20, p. 10-pg., . (19/26263-4, 19/22724-7, 17/02147-0, 14/03765-0, 15/15462-5, 14/07347-9)
MACIEL, EDVALDO VASCONCELOS SOARES; MEDINA, DEYBER ARLEY VARGAS; BORSATTO, JOAO VICTOR BASSOLLI; LANCAS, FERNANDO MAURO. Towards a universal automated and miniaturized sample preparation approach. SUSTAINABLE CHEMISTRY AND PHARMACY, v. 21, . (17/02147-0, 14/03765-0, 19/22724-7, 14/07347-9)
SARTORE, DOUGLAS M.; MEDINA, DEYBER VARGAS A.; BOCELLI, MARCIO D.; JORDAN-SINISTERRA, MARCELA; SANTOS-NETO, ALVARO J.; LANCAS, FERNANDO M.. Modern automated microextraction procedures for bioanalytical, environmental, and food analyses. JOURNAL OF SEPARATION SCIENCE, v. 46, n. 15, p. 30-pg., . (17/02147-0, 19/22724-7, 15/15462-5, 14/07347-9)
BOCELLI, MARCIO DAVID; MEDINA, DEYBER ARLEY VARGAS; LANCAS, FERNANDO MAURO; DOS SANTOS-NETO, ALVARO JOSE. Automated microextraction by packed sorbent of endocrine disruptors in wastewater using a high-throughput robotic platform followed by liquid chromatography-tandem mass spectrometry. ANALYTICAL AND BIOANALYTICAL CHEMISTRY, v. N/A, p. 12-pg., . (17/02147-0, 19/22724-7, 15/15462-5, 14/07347-9)