Novel instrumental approaches for automated and miniaturized analytical methods for the detection of organic compounds by liquid chromatography coupled to mass spectrometry

• Grant number: 19/22724-7
• Support type: Scholarships in Brazil - Post-Doctorate
• Effective date (Start): February 01, 2020
• Effective date (End): January 31, 2022
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Analytical Chemistry
• Principal researcher: Fernando Mauro Lanças
• Grantee: Deyber Arley Vargas Medina
• Home Institution: Instituto de Química de São Carlos (IQSC). Universidade de São Paulo (USP). São Carlos , SP, Brazil
• Associated research grant: 17/02147-0 - Single drop chromatography and its coupling to mass spectrometry: instrumental strategies, development of materials, automation and analytical applications, AP.TEM

Abstract

The main demand in modern Analytical Chemistry is the development of ever faster, simpler and more efficient methods which, through the appropriate combination of sample preparation, chromatography and mass spectrometry, will provide reliable results in a short time and with minimal environmental impact. Thus, the present project seeks to assist the main thematic project, by developing comprehensive and high productivity analytical systems. Three main axes of the thematic project will be addressed in the implementation of this proposal: (i) development of automated sample preparation methods to simplify high throughput analysis; (ii) introduction and fabrication of new miniaturized chromatographic columns, in chip format with built-in temperature programming system capable of separating small molecules with high efficiency and speed; and (iii) coupling of the previous systems with electrospray ionization source mass spectrometry (ESI-MS) detection. ) and electron assisted (EI-MS), focusing on the development of targeted and untargeted analytical applications. (AU)

Scientific publications

(7)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

MACIEL, EDVALDO VASCONCELOS SOARES; MEDINA, DEYBER ARLEY VARGAS; BORSATTO, JOAO VICTOR BASSOLLI; LANCAS, FERNANDO MAURO. Towards a universal automated and miniaturized sample preparation approach. SUSTAINABLE CHEMISTRY AND PHARMACY, v. 21, JUN 2021. Web of Science Citations: 0.

VARGAS MEDINA, DEYBER ARLEY; PEREIRA DOS SANTOS, NATALIA GABRIELLY; DA SILVA BURATO, JULIANA SOARES; BASOLLI BORSATTO, JOAO VICTOR; LANCAS, FERNANDO MAURO. An overview of open tubular liquid chromatography with a focus on the coupling with mass spectrometry for the analysis of small molecules. Journal of Chromatography A, v. 1641, MAR 29 2021. Web of Science Citations: 0.

AKAMINE, LIDIA AKEMI; MEDINA, DEYBER ARLEY VARGAS; LANCAS, FERNANDO MAURO. Magnetic solid-phase extraction of gingerols in ginger containing products. Talanta, v. 222, JAN 15 2021. Web of Science Citations: 0.

DA SILVA, LUIS FELIPE; VARGAS MEDINA, DEYBER ARLEY; LANCAS, FERNANDO MAURO. Automated needle-sleeve based online hyphenation of solid-phase microextraction and liquid chromatography. Talanta, v. 221, JAN 1 2021. Web of Science Citations: 0.

SARTORE, DOUGLAS MORISUE; VARGAS MEDINA, DEYBER ARLEY; COSTA, JOSE LUIZ; LANCAS, FERNANDO MAURO; SANTOS-NETO, ALVARO JOSE. Automated microextraction by packed sorbent of cannabinoids from human urine using a lab-made device packed with molecularly imprinted polymer. Talanta, v. 219, NOV 1 2020. Web of Science Citations: 0.

VARGAS MEDINA, DEYBER ARLEY; SOARES MACIEL, EDVALDO VASCONCELOS; LANCAS, FERNANDO MAURO. Miniaturization of liquid chromatography coupled to mass spectrometry. 3. Achievements on chip-based LC-MS devices. TRAC-TRENDS IN ANALYTICAL CHEMISTRY, v. 131, OCT 2020. Web of Science Citations: 0.

VARGAS MEDINA, DEYBER ARLEY; SOARES MACIEL, EDVALDO VASCONCELOS; DE TOFFOLI, ANA LUCIA; LANCAS, FERNANDO MAURO. Miniaturization of liquid chromatography coupled to mass spectrometry. 2. Achievements on modern instrumentation for miniaturized liquid chromatography coupled to mass spectrometry. TRAC-TRENDS IN ANALYTICAL CHEMISTRY, v. 128, JUL 2020. Web of Science Citations: 0.