Novel instrumental approaches for automated and miniaturized analytical methods for the detection of organic compounds by liquid chromatography coupled to mass spectrometry

• Grant number: 19/22724-7
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• Start date: February 01, 2020
• End date: January 31, 2023
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Analytical Chemistry
• Principal Investigator: Fernando Mauro Lanças
• Grantee: Deyber Arley Vargas Medina
• Host Institution: Instituto de Química de São Carlos (IQSC). Universidade de São Paulo (USP). São Carlos , SP, Brazil
• Associated research grant: 17/02147-0 - Single drop chromatography and its coupling to mass spectrometry: instrumental strategies, development of materials, automation and analytical applications, AP.TEM

Abstract

The main demand in modern Analytical Chemistry is the development of ever faster, simpler and more efficient methods which, through the appropriate combination of sample preparation, chromatography and mass spectrometry, will provide reliable results in a short time and with minimal environmental impact. Thus, the present project seeks to assist the main thematic project, by developing comprehensive and high productivity analytical systems. Three main axes of the thematic project will be addressed in the implementation of this proposal: (i) development of automated sample preparation methods to simplify high throughput analysis; (ii) introduction and fabrication of new miniaturized chromatographic columns, in chip format with built-in temperature programming system capable of separating small molecules with high efficiency and speed; and (iii) coupling of the previous systems with electrospray ionization source mass spectrometry (ESI-MS) detection. ) and electron assisted (EI-MS), focusing on the development of targeted and untargeted analytical applications. (AU)

Scientific publications

(29)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

VARGAS MEDINA, DEYBER ARLEY; SOARES MACIEL, EDVALDO VASCONCELOS; DE TOFFOLI, ANA LUCIA; LANCAS, FERNANDO MAURO. Miniaturization of liquid chromatography coupled to mass spectrometry. 2. Achievements on modern instrumentation for miniaturized liquid chromatography coupled to mass spectrometry. TRAC-TRENDS IN ANALYTICAL CHEMISTRY, v. 128, JUL 2020. (17/02147-0, 15/15462-5, 14/07347-9, 19/22724-7)

VARGAS MEDINA, DEYBER ARLEY; PEREIRA DOS SANTOS, NATALIA GABRIELLY; DA SILVA BURATO, JULIANA SOARES; BASOLLI BORSATTO, JOAO VICTOR; LANCAS, FERNANDO MAURO. An overview of open tubular liquid chromatography with a focus on the coupling with mass spectrometry for the analysis of small molecules. Journal of Chromatography A, v. 1641, MAR 29 2021. (19/26263-4, 19/22724-7, 14/07347-9, 17/02147-0, 14/03765-0, 15/15462-5)

SARTORE, DOUGLAS MORISUE; VARGAS MEDINA, DEYBER ARLEY; COSTA, JOSE LUIZ; LANCAS, FERNANDO MAURO; SANTOS-NETO, ALVARO JOSE. Automated microextraction by packed sorbent of cannabinoids from human urine using a lab-made device packed with molecularly imprinted polymer. Talanta, v. 219, NOV 1 2020. (17/02147-0, 19/22724-7, 10/19910-9)

AKAMINE, LIDIA AKEMI; MEDINA, DEYBER ARLEY VARGAS; LANCAS, FERNANDO MAURO. Magnetic solid-phase extraction of gingerols in ginger containing products. Talanta, v. 222, JAN 15 2021. (17/02147-0, 10/19910-9, 19/22724-7)

DA SILVA, LUIS FELIPE; VARGAS MEDINA, DEYBER ARLEY; LANCAS, FERNANDO MAURO. Automated needle-sleeve based online hyphenation of solid-phase microextraction and liquid chromatography. Talanta, v. 221, JAN 1 2021. (14/07347-9, 14/03765-0, 15/15462-5, 17/02147-0, 19/22724-7)

BORSATTO, JOAO V. B.; MACIEL, EDVALDO V. S.; CIFUENTES, ALEJANDRO; LANCAS, FERNANDO M.. Online Extraction Followed by LC-MS/MS Analysis of Lipids in Natural Samples: A Proof-of-Concept Profiling Lecithin in Seeds. FOODS, v. 12, n. 2, p. 12-pg., 2023-01-01. (17/02147-0, 19/22724-7)

VARGAS MEDINA, DEYBER ARLEY; SOARES MACIEL, EDVALDO VASCONCELOS; LANCAS, FERNANDO MAURO. Miniaturization of liquid chromatography coupled to mass spectrometry. 3. Achievements on chip-based LC-MS devices. TRAC-TRENDS IN ANALYTICAL CHEMISTRY, v. 131, OCT 2020. (19/22724-7, 14/03765-0, 15/15462-5, 17/02147-0, 14/07347-9)

SOARES MACIEL, EDVALDO VASCONCELOS; PEREIRA DOS SANTOS, NATALIA GABRIELLY; VARGAS MEDINA, DEYBER ARLEY; LANCAS, FERNANDO MAURO. Electron ionization mass spectrometry: Quo vadis?. ELECTROPHORESIS, v. 43, n. 15, p. 14-pg., 2022-05-20. (19/26263-4, 19/22724-7, 17/02147-0, 14/03765-0, 15/15462-5, 14/07347-9)

DOS SANTOS, NATALIA GABRIELLY; MEDINA, DEYBER ARLEY VARGAS; LANCAS, FERNANDO MAURO. Microextraction by packed sorbent of N-nitrosamines from Losartan tablets using a high-throughput robot platform followed by liquid chromatography-tandem mass spectrometry. JOURNAL OF SEPARATION SCIENCE, v. 46, n. 17, p. 13-pg., 2023-07-03. (15/15462-5, 19/22724-7, 17/02147-0, 14/07347-9, 19/26263-4)

DOS SANTOS, NATALIA GABRIELLY PEREIRA; MACIEL, EDVALDO VASCONCELOS SOARES; MEDINA, DEYBER ARLEY VARGAS; LANCAS, FERNANDO MAURO. NanoLC-EI-MS: Perspectives in Biochemical Analysis. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v. 24, n. 14, p. 14-pg., 2023-07-01. (19/22724-7, 17/21984-0, 17/02147-0, 17/21985-6, 19/26263-4)

ANDRADE, FELIPE N.; SANTOS-NETO, ALVARO JOSE; MEDINA, DEYBER ARLEY V.; LANCAS, FERNANDO M.. A molecularly imprinted polymer for microextraction by packed sorbent of sulfonylureas herbicides from corn samples. Journal of Food Composition and Analysis, v. 121, p. 7-pg., 2023-05-12. (15/15462-5, 11/09898-4, 19/22724-7, 17/02147-0, 14/07347-9, 13/17425-4)

OLIVEIRA, THAIS CAMAROTTO; LANCAS, FERNANDO MAURO. Determination of selected herbicides employed in sugarcane crops by disposable pipette tip (DPX) extraction followed by LC-MS/MS and GC-MS/MS. Journal of Liquid Chromatography & Related Technologies, v. 44, n. 17-20, p. 8-pg., 2022-08-22. (17/02147-0, 14/07347-9, 19/22724-7, 15/15462-5)

DA SILVA BURATO, JULIANA SOARES; BASOLLI BORSATTO, JOAO VICTOR; LANCAS, FERNANDO MAURO. Practical aspects of preparation, optimization, and evaluation of poly (styrene-divinylbenzene)porous-layer open tubular (PLOT) columns for capillary liquid chromatography. Talanta, v. 253, p. 7-pg., 2023-02-01. (17/02147-0, 14/07347-9, 19/22724-7, 15/15462-5)

BORSATTO, JOAO V. B.; LANCAS, FERNANDO M. M.. Recent Trends in Graphene-Based Sorbents for LC Analysis of Food and Environmental Water Samples. Molecules, v. 28, n. 13, p. 21-pg., 2023-07-01. (17/02147-0, 19/22724-7)

MEDINA, DEYBER ARLEY VARGAS; MACIEL, EDVALDO VASCONCELOS SOARES; DOS SANTOS, NATALIA GABRIELLY PEREIRA; LANCAS, FERNANDO MAURO. The overshadowed role of electron ionization-mass spectrometry in analytical biotechnology. CURRENT OPINION IN BIOTECHNOLOGY, v. 82, p. 9-pg., 2023-06-30. (17/02147-0, 19/22724-7)

MACIEL, EDVALDO VASCONCELOS SOARES; MEDINA, DEYBER ARLEY VARGAS; BORSATTO, JOAO VICTOR BASSOLLI; LANCAS, FERNANDO MAURO. Towards a universal automated and miniaturized sample preparation approach. SUSTAINABLE CHEMISTRY AND PHARMACY, v. 21, JUN 2021. (17/02147-0, 14/03765-0, 19/22724-7, 14/07347-9)

JORDAN-SINISTERRA, MARCELA; VARGAS MEDINA, DEYBER ARLEY; LANCAS, FERNANDO MAURO. Microextraction by packed sorbent of polycyclic aromatic hydrocarbons in brewed coffee samples with a new zwitterionic ionic liquid-modified silica sorbent. Journal of Food Composition and Analysis, v. 114, p. 9-pg., 2022-08-27. (14/07347-9, 19/22724-7, 17/02147-0, 15/15462-5)

SARTORE, DOUGLAS M.; MEDINA, DEYBER VARGAS A.; BOCELLI, MARCIO D.; JORDAN-SINISTERRA, MARCELA; SANTOS-NETO, ALVARO J.; LANCAS, FERNANDO M.. Modern automated microextraction procedures for bioanalytical, environmental, and food analyses. JOURNAL OF SEPARATION SCIENCE, v. 46, n. 15, p. 30-pg., 2023-05-26. (17/02147-0, 19/22724-7, 15/15462-5, 14/07347-9)

BOCELLI, MARCIO DAVID; MEDINA, DEYBER ARLEY VARGAS; LANCAS, FERNANDO MAURO; DOS SANTOS-NETO, ALVARO JOSE. Automated microextraction by packed sorbent of endocrine disruptors in wastewater using a high-throughput robotic platform followed by liquid chromatography-tandem mass spectrometry. ANALYTICAL AND BIOANALYTICAL CHEMISTRY, v. N/A, p. 12-pg., 2023-08-03. (17/02147-0, 19/22724-7, 15/15462-5, 14/07347-9)

MEDINA, DEYBER ARLEY VARGAS; MACIEL, EDVALDO VASCONCELOS SOARES; LANCAS, FERNANDO MAURO. Modern automated sample preparation for the determination of organic compounds: A review on robotic and on-flow systems. TRAC-TRENDS IN ANALYTICAL CHEMISTRY, v. 166, p. 21-pg., 2023-09-01. (17/02147-0, 19/22724-7, 17/21984-0, 17/21985-6)

MEDINA, DEYBER ARLEY VARGAS; CARDOSO, ALESSANDRA TIMOTEO; BORSATTO, JOAO VICTOR BASOLLI; LANCAS, FERNANDO MAURO. Open tubular liquid chromatography: Recent advances and future trends. JOURNAL OF SEPARATION SCIENCE, v. N/A, p. 22-pg., 2023-08-15. (17/02147-0, 19/22724-7)

VARGAS MEDINA, DEYBER ARLEY; PEREIRA DOS SANTOS, NATALIA GABRIELLY; SOARES MACIEL, EDVALDO VASCONCELOS; LANCAS, FERNANDO MAURO. Current prospects on nano liquid chromatography coupled to electron ionization mass spectrometry (nanoLC-EI-MS). Journal of Liquid Chromatography & Related Technologies, v. 44, n. 17-20, p. 10-pg., 2022-08-17. (19/26263-4, 19/22724-7, 17/02147-0, 14/03765-0, 15/15462-5, 14/07347-9)

OLIVEIRA, THAIS CAMAROTTO; LANCAS, FERNANDO MAURO. Determination of selected herbicides in sugarcane-derived foods by graphene-oxide based disposable pipette extraction followed by liquid chromatography-tandem mass spectrometry. Journal of Chromatography A, v. 1687, p. 11-pg., 2023-01-04. (17/02147-0, 19/22724-7, 14/07347-9, 15/15462-5)

BORSATTO, JOAO V. B.; MACIEL, EDVALDO V. S.; LANCAS, FERNANDO M.. Investigation of the applicability of silica-graphene hybrid materials as stationary phases for capillary liquid chromatography. Journal of Chromatography A, v. 1685, p. 8-pg., 2022-11-04. (17/02147-0, 19/22724-7, 14/07347-9, 15/15462-5)

MEDINA, DEYBER ARLEY VARGAS; CARDOSO, ALESSANDRA TIMOTEO; MACIEL, EDVALDO VASCONCELOS SOARES; LANCAS, FERNANDO M.. Current materials for miniaturized sample preparation: Recent advances and future trends. TRAC-TRENDS IN ANALYTICAL CHEMISTRY, v. 165, p. 26-pg., 2023-06-09. (17/02147-0, 19/22724-7, 17/21984-0, 17/21985-6)

BORSATTO, JOAO VICTOR BASOLLI; MACIEL, EDVALDO VASCONCELOS SOARES; CIFUENTES, ALEJANDRO; LANCAS, FERNANDO MAURO. Applicability and Limitations of a Capillary-LC Column-Switching System Using Hybrid Graphene-Based Stationary Phases. Molecules, v. 28, n. 13, p. 14-pg., 2023-07-01. (17/02147-0, 19/22724-7)

SANTOS, NATALIA G. P.; MEDINA, DEYBER A. V.; LANCAS, FERNANDO M.. Development of Wall-Coated Open Tubular Columns and Their Application to Nano Liquid Chromatography Coupled to Tandem Mass Spectrometry. Molecules, v. 28, n. 13, p. 15-pg., 2023-07-01. (15/15462-5, 19/22724-7, 17/02147-0, 14/07347-9, 19/26263-4)

BOCELLI, MARCIO DAVID; VARGAS MEDINA, DEYBER ARLEY; GARCIA RODRIGUEZ, JULIE PAULIN; LANCAS, FERNANDO MAURO; SANTOS-NETO, ALVARO JOSE. Determination of parabens in wastewater samples via robot-assisted dynamic single-drop microextraction and liquid chromatography-tandem mass spectrometry. ELECTROPHORESIS, v. 43, n. 15, p. 10-pg., 2022-05-26. (17/02147-0, 19/22724-7, 14/07347-9, 15/15462-5)

MEDINA, DEYBER ARLEY VARGAS; BURATO, JULIANA SOARES DA SILVA; BORSATTO, JOAO VICTOR BASOLLI; LANCAS, FERNANDO MAURO. Porous layer open tubular nano liquid chromatography directly coupled to electron ionization mass spectrometry. Journal of Chromatography A, v. 1674, p. 9-pg., 2022-05-16. (17/02147-0, 19/22724-7, 14/07347-9, 15/15462-5)