Chemopreventive Effects of (-)-Hinokinin against 1,2-Dimethylhydrazine-Induced Genotoxicity and Preneoplastic Lesions in Rat Colon

Autor(es)

Barbosa, Lilian C. ^[1] ; Furtado, Ricardo A. ^[1] ; Bertanha, Humberto C. C. ^[1] ; Tomazella, Iara M. ^[1] ; Costa, Eveline S. ^[1] ; Bastos, Jairo K. ^[2] ; Andrade e Silva, Marcio L. ^[1] ; Tavares, Denise C. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Franca, BR-14404600 Sao Paulo - Brazil

^[2] Univ Sao Paulo, Fac Ciencias Farmaceut Ribeirao Preto, BR-14040903 Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Journal of Natural Products; v. 77, n. 10, p. 2312-2315, OCT 2014.
• Citações Web of Science: 4

Resumo

(-)-Hinokinin (1) is a dibenzylbutyrolactone lignan obtained by the partial synthesis of (-)-cubebin. This study reports the antigenotoxic and anticarcinogenic potential of 1 by the comet and aberrant crypt focus assays in the peripheral blood and colon of 4-5-week-old Wistar rats, respectively. The rats were exposed to 1,2-dimethylhydrazine (40 mg/kg) and were treated by gavage with doses of 10, 20, and 40 mg/kg of 1. The results showed that the dose of 40 mg/kg was neither genotoxic nor carcinogenic. In the comet assay, all 1 doses displayed antigenotoxic effects. In addition, this compound (20 and 40 mg/kg) exhibited an anticarcinogenic effect in the aberrant crypt focus assay. (AU)

• Processo FAPESP: 08/02211-0 - Avaliação do efeito do ácido rosmarínico sobre os danos de dna em células de mamíferos in vivo e in vitro e sobre a carcinogênese de cólon de ratos
• Beneficiário: Ricardo Andrade Furtado
• Modalidade de apoio: Bolsas no Brasil - Mestrado